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Merck

F5421

Sigma-Aldrich

Anti-Fibroblast Growth Factor Receptor-1 antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

Sinónimos:

Anti-FGFR-1

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About This Item

Número MDL:
Código UNSPSC:
51111800
NACRES:
NA.41

origen biológico

rabbit

Nivel de calidad

conjugado

unconjugated

forma del anticuerpo

affinity isolated antibody

tipo de anticuerpo

primary antibodies

clon

polyclonal

formulario

buffered aqueous solution

mol peso

antigen 110-120 kDa

reactividad de especies

human

envase

antibody small pack of 25 μL

concentración

~1 mg/mL

técnicas

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:200 using trypsin-digested human and animal tissue sections
immunoprecipitation (IP): suitable
western blot: 1:400 using an extract of FGFR-1 transfected cells

Nº de acceso UniProt

Condiciones de envío

dry ice

temp. de almacenamiento

−20°C

modificación del objetivo postraduccional

unmodified

Información sobre el gen

human ... FGFR1(2260)

Descripción general

Fibroblast growth factor receptor 1 (FGFR-1) belongs to the family of FGFRs. At the mRNA level, FGFR-1 is highly expressed in developing human tissues including the brain (preferentially in neurons), vascular basement membranes, skin, and bone growth plates.

Especificidad

Anti-FGFR-1 antibody is specific for human FGFR-1 and does not react with human FGFR-2 and FGFR-3. The immunizing peptide specifically inhibits the staining of anti-FGFR-1 antibody.
Staining of the product is specifically inhibited with the FGFR-1 immunizing peptide. No reaction with human FGFR-2 and FGFR-3 is detected.
No reaction with FGFR-2 (Bek) and FGFR-3 is detected.

Inmunógeno

Synthetic peptide corresponding to amino acid residues 360-373 of the extracellular region of human FGFR-1 conjugated to KLH with glutaraldehyde, and with a C-terminally added lysine.

Aplicación

Anti-Fibroblast Growth Factor Receptor-1 antibody produced in rabbit has been used in:
  • immunoprecipitation
  • immunofluorocytochemistry
  • immunohistochemistry
  • immunoblotting

Forma física

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Visite la Librería de documentos

Hichem Miraoui et al.
Molecular and cellular endocrinology, 346(1-2), 37-43 (2011-06-15)
Fibroblast growth factor (FGF) signaling is critical for a broad range of developmental processes. In 2003, Fibroblast growth factor receptor 1 (FGFR1) was discovered as a novel locus causing both forms of isolate GnRH Deficiency, Kallmann syndrome [KS with anosmia]
A Decade of FGF Receptor Research in Bladder Cancer: Past, Present, and Future Challenges.
di Martino, E., et al.
Advances in Urology, doi: 10-doi: 10 (2012)
Two FGF receptor genes are differentially expressed in epithelial and mesenchymal tissues during limb formation and organogenesis in the mouse
Peters KG, et al.
Development, 114 (1992)
Heike Hall et al.
Microvascular research, 68(3), 169-178 (2004-10-27)
Angiogenic signals can be matrix attached or freely diffusible. Here, the sixth Ig-like domain of L1 (L1Ig6), a ligand for alphavbeta3-integrin, was investigated. This domain was expressed as a fusion protein having a substrate sequence for factor XIII to enable
Fibroblast growth factor-20 protects against dopamine neuron loss in vitro and provides functional protection in the 6-hydroxydopamine-lesioned rat model of Parkinson's disease
Sleeman IJ, et al.
Neuropharmacology, 63 (2012)

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