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E8750

Sigma-Aldrich

α-Estradiol

powder, ≥98% (TLC)

Sinónimos:

1,3,5(10)-Estratriene-3,17α-diol, 3,17α-Dihydroxy-1,3,5(10)-estratriene, Epiestradiol

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About This Item

Fórmula empírica (notación de Hill):
C18H24O2
Número de CAS:
57-91-0
Peso molecular:
272.38
Número CE:
200-354-8
Número MDL:
MFCD00064144
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
24894682
NACRES:
NA.77

origen biológico

synthetic (organic)

Nivel de calidad

200

Ensayo

≥98% (TLC)

Formulario

powder

color

white to slight yellow

solubilidad

ethanol: 50 mg/mL, clear, colorless

Condiciones de envío

ambient

temp. de almacenamiento

room temp

cadena SMILES

[H][C@]12CC[C@]3(C)[C@H](O)CC[C@@]3([H])[C@]1([H])CCc4cc(O)ccc24

InChI

1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17-,18+/m1/s1

Clave InChI

VOXZDWNPVJITMN-SFFUCWETSA-N

Información sobre el gen

human ... ESR1(2099) , ESR2(2100)
rat ... Ar(24208)

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Acciones bioquímicas o fisiológicas

Estradiol (known as alpha Estradiol or 17 alpha Estradiol) is a biologically active estrogen in human breast cancer cells in tissue culture.17-estradiol and its selective receptor, ER-X, are not part of a classical hormone/receptor endocrine system but of a system with important autocrine/paracrine functions in the developing and adult brain. 17-Estradiol may have enormous implications for hormone replacement strategies at the menopause and in the treatment of such neurodegenerative disorders as Alzheimer′s disease and ischemic stroke.

Pictogramas

Health hazardEnvironment
GHS08,GHS09

Palabra de señalización

Danger

Frases de peligro

H341,H351,H360F,H362,H410

Clasificaciones de peligro

Aquatic Chronic 1 - Carc. 2 - Lact. - Muta. 2 - Repr. 1A

Código de clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Clase de riesgo para el agua (WGK)

WGK 3

Equipo de protección personal

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
099M4088V
13190414
039M4115V
13181111
108M4011V

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Wolf Dietrich et al.
Fertility and sterility, 95(4), 1247-1255 (2010-12-07)
To clarify, whether uterine endothelial proliferation could be regulated via an autocrine estrogen producing mechanism or direct actions of testosterone. In vitro study. Tertiary care facility. Human myometrial tissue obtained from 40 women undergoing hysterectomy without further intrauterine pathology. Cell
Jennifer R Wardell et al.
Biology of reproduction, 89(5), 116-116 (2013-09-27)
Estrogen signaling in the ovary is a fundamental component of normal ovarian function, and evidence also indicates that excessive estrogen is a risk factor for ovarian cancer. We have previously demonstrated that the gonadally enriched TFIID subunit TAF4B, a paralog
C Y Cheng et al.
Fertility and sterility, 32(5), 566-570 (1979-11-01)
In modified Tyrode's solution, 17 beta-estradiol at concentrations between 0.1 microgram/ml and 320 nmoles/ml was effective in increasing human spermatozoal forward migration. 17 alpha-Estradiol, although structurally similar to 17 beta-estradiol, had no effect on human spermatozoal motility. DL-Norgestrel at concentrations
J Pitt et al.
Journal of inherited metabolic disease, 25(2), 83-88 (2002-07-18)
Three patients with ketosis had increased excretion of 3-hydroxyglutarate (21.8-37.9 micromol/mmol creatinine; controls 2.3 +/- 1.6), an indicator of glutaryl-CoA dehydrogenase deficiency (GDHD), which normalized when the patients were nonketotic. Clinical assessment of all three patients and enzyme studies in
Cristian G Bologa et al.
Nature chemical biology, 2(4), 207-212 (2006-03-08)
Estrogen is a hormone critical in the development, normal physiology and pathophysiology of numerous human tissues. The effects of estrogen have traditionally been solely ascribed to estrogen receptor alpha (ERalpha) and more recently ERbeta, members of the soluble, nuclear ligand-activated
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UHPLC Analysis of Conjugated Estrogens on Ascentis ® Express C18

Separation of Estriol 3-(β-D-glucuronide) sodium salt; β-Estradiol 3-(β-D-glucuronide) 17-sulfate dipotassium salt; Estriol 3-sulfate sodium salt; β-Estradiol 3,17-disulfate dipotassium salt, ≥95%; β-Estradiol 17-(β-D-glucuronide) sodium salt; β-Estradiol 3-(β-D-glucuronide) sodium salt; Estrone 3-(β-D-glucuronide) sodium salt; β-Estradiol 3-sulfate sodium salt, ≥93%; Estriol, ≥97%; Estrone 3-sulfate sodium salt, contains ~35% Tris as stabilizer; β-Estradiol, ≥98%; α-Estradiol, powder, ≥98% (TLC); Estrone, ≥99%

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