E5161

Enniatin A1

from Gnomonia errabunda, ≥95% (HPLC)

• Sinónimos: 2-(N-Methyl-L-valine) Enniatin A, Cyclo[(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-isoleucyl-(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-isoleucyl-(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-valyl]
• Fórmula empírica (notación de Hill): C₃₅H₆₁N₃O₉
• Número de CAS: 4530-21-6
• Peso molecular: 667.87
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• origen biológico: Gnomonia errabunda
• Nivel de calidad: 200
• Análisis: ≥95% (HPLC)
• solubilidad: DMSO: 10 mg/mL; ethanol: 10 mg/mL; methanol: 10 mg/mL
• temp. de almacenamiento: −20°C
• InChI: 1S/C35H61N3O9/c1-16-22(11)25-34(43)46-27(19(5)6)30(39)36(13)24(18(3)4)33(42)45-28(20(7)8)31(40)37(14)26(23(12)17-2)35(44)47-29(21(9)10)32(41)38(25)15/h18-29H,16-17H2,1-15H3/t22-,23-,24-,25-,26-,27+,28+,29+/m0/s1
• Clave InChI: OWUREPXBPJFMOK-CIRFPNLUSA-N

Descripción

Acciones bioquímicas o fisiológicas

Enniatins are a group of cyclohexadepsipeptide mycotoxins produced by Gnomonia errabuda and several Fusaria species, with phytotoxic, antibiotic, and insecticidal activities. Enniatins function as ionophors by their incorporation into the cellular membrane to form dimeric structures that transport monovalent ions across the membrane (especially the mitochondrial membranes) affecting oxidative phosphorylation uncoupling. It has been demonstrated that enniatins have a cytotoxic effect on human cancer cells. Furthermore, incubation of H4IIE hepatoma cells with enniatins strongly diminished phosphorylation of the ERK (p44/p42).

Información de seguridad

• Pictogramas: GHS06
• Palabra de señalización: Danger
• Frases de peligro: H301 + H311 + H331
• Consejos de prudencia: P261 - P264 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P311
• Clasificaciones de peligro: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral
• Código de clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable