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Merck

D7810

Sigma-Aldrich

Anti-Daxx antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Sinónimos:

Anti-BING2, Anti-DAP6, Anti-EAP1, Anti-SMIM40

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About This Item

Número MDL:
Código UNSPSC:
12352203
NACRES:
NA.41

origen biológico

rabbit

conjugado

unconjugated

forma del anticuerpo

IgG fraction of antiserum

tipo de anticuerpo

primary antibodies

clon

polyclonal

formulario

buffered aqueous solution

mol peso

antigen 120 kDa

reactividad de especies

mouse, human, monkey

técnicas

microarray: suitable
western blot: 1:4,000 using human acute lymphoma Jurkat whole cell extract

Nº de acceso UniProt

Condiciones de envío

dry ice

temp. de almacenamiento

−20°C

modificación del objetivo postraduccional

unmodified

Información sobre el gen

human ... DAXX(1616)
mouse ... Daxx(13163)

Descripción general

Death domain associated protein (Daxx), also known as ETS associated protein 1 (EAP1), is an adaptor protein that binds to the death domain of Fas. Daxx is a 120 kDa protein with a nuclear localization signal sequence. It is highly acidic due to extended glutamic acid-rich domains. Daxx mRNA is extensively expressed in fetal and adult human and mouse tissues. Daxx has also been found in the nucleus where it localizes with the promyelocytic leukemia protein (PML), a gene of acute promyelocytic leukemia (APL).

Especificidad

Anti-Daxx specifically recognizes human Daxx (120 kDa).

Inmunógeno

Synthetic peptide corresponding to the C-terminus of human Daxx. This sequence is identical in mouse and monkey.

Aplicación

Anti-Daxx antibody is suitable for:
  • western blot (1:4,000 using human acute lymphoma Jurkat whole cell extract)
  • microarray
  • the detection and localization of Daxx by immunoblotting

Anti-Daxx antibody produced in rabbit has been used to visualize hDaxx.

Acciones bioquímicas o fisiológicas

The death domain-associated protein (Daxx) is a protein that interacts with FAS and subsequently regulates cellular apoptosis. Daxx also interacts with H3.3 histone and α-thalassemia X-linked mental retardation protein (ATRX) to regulate chromatin deposition at telomeres. In addition, it also acts as a pro-apoptotic molecule that can specifically enhance Fas-induced apoptosis by activating the Jun N-terminal kinase (JNK) signaling pathway, through its interaction with the apoptosis signal-regulating kinase 1 (ASK1).

Forma física

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Opcional

Referencia del producto
Descripción
Precios

Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Visite la Librería de documentos

Human cytomegalovirus immediate-early gene expression is restricted by the nuclear domain 10 component Sp100
Adler M, et al.
The Journal of General Virology, 92(7), 1532-1538 (2011)
Ryan T Saffert et al.
Journal of virology, 84(11), 5594-5604 (2010-03-26)
Human cytomegalovirus (HCMV) persists for the life of its host by establishing a latent infection. The identification of viral and cellular determinants of latency is the first step toward developing antiviral treatments that target and might clear or control the
Components of promyelocytic leukemia nuclear bodies (ND10) act cooperatively to repress herpesvirus infection
Glass M and Everett D, et al.
Journal of Virology, 87(4), 2174-2185 (2013)
EAP1/Daxx interacts with ETS1 and represses transcriptional activation of ETS1 target genes
Li R, et al.
Oncogene, 19(6), 745-745 (2000)
Ryan T Saffert et al.
Journal of virology, 80(8), 3863-3871 (2006-03-31)
Human cytomegalovirus (HCMV) masterfully evades adaptive and innate immune responses, allowing infection to be maintained and periodically reactivated for the life of the host. Here we show that cells also possess an intrinsic immune defense against HCMV that is disarmed

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