D3938
Anti-DR5 antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Sinónimos:
Anti-Death Receptor 5, Anti-KILLER, Anti-TRAIL-R2, Anti-TRICK2
Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización
About This Item
Número MDL:
Código UNSPSC:
12352203
origen biológico
rabbit
conjugado
unconjugated
forma del anticuerpo
affinity isolated antibody
tipo de anticuerpo
primary antibodies
clon
polyclonal
Formulario
buffered aqueous solution
mol peso
antigen 57 kDa
reactividad de especies
human
técnicas
microarray: suitable
western blot: 2 μg/mL using human HeLa and K562 cell extracts
Nº de acceso UniProt
Condiciones de envío
dry ice
temp. de almacenamiento
−20°C
Información sobre el gen
human ... TNFRSF10B(8795)
Descripción general
DR5 is a death domain-containing receptor that is activated through a p53-depedent pathway in response to radiation and DNA damage . DR5 is involved in caspase activation and cell apoptosis . Anti-DR5 antibody is specific for DR5 in humans.
Inmunógeno
synthetic peptide corresponding to amino acids 388-407 of the human DR5 precursor.
Aplicación
Anti-DR5 antibody may be used in western blot (1 μg/mL using human HeLa and K562 cell extracts), immunoblot and microarray.
Forma física
Solution in phosphate buffered saline containing 0.02% sodium azide
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
¿No encuentra el producto adecuado?
Pruebe nuestro Herramienta de selección de productos.
Opcional
Referencia del producto
Descripción
Precios
Código de clase de almacenamiento
12 - Non Combustible Liquids
Clase de riesgo para el agua (WGK)
nwg
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Elija entre una de las versiones más recientes:
¿Ya tiene este producto?
Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
R Takimoto et al.
Oncogene, 19(14), 1735-1743 (2000-04-25)
KILLER/DR5, a tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor gene, has been shown to be induced by DNA damaging agents and radiation in a p53-dependent manner. Although TRAIL is a potential therapeutic agent for cancer, the induction mechanism of
G S Wu et al.
Oncogene, 18(47), 6411-6418 (1999-12-22)
The TRAIL death receptor KILLER/DR5 is induced by DNA damaging agents in wild-type p53-expressing cells. Here we show that, unlike the p53-target CDK-inhibitor p21WAF1/CIP1, the TRAIL death receptor KILLER/DR5 is only induced in cells undergoing p53-dependent apoptosis and not cell
Giovanni Migliaccio et al.
Blood cells, molecules & diseases, 47(3), 182-197 (2011-07-22)
The number of erythroblasts generated ex-vivo under human-erythroid massive-amplification conditions by mononuclear cells from one unit of adult blood (~10(10)) are insufficient for transfusion (~10(12) red cells), emphasizing the need for studies to characterize cellular interactions during culture to increase
Alan D Brooks et al.
Molecular cancer research : MCR, 8(5), 729-738 (2010-05-06)
Bortezomib (VELCADE) could sensitize certain human renal cell carcinoma (RCC) lines to the apoptotic effects of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Analysis of seven human RCC showed a clear increase in the sensitivity of four of the RCC to
Henning Walczak et al.
Methods in molecular biology (Clifton, N.J.), 414, 221-239 (2008-01-08)
The extrinsic apoptosis pathway is activated when certain members of the tumor necrosis factor (TNF) receptor superfamily (TNFRSF) are oligomerized by their cognate ligands that are members of the TNF superfamily (TNFSF). The apoptosis-inducing capacity of a member of the
Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.
Póngase en contacto con el Servicio técnico