D3196

Dipeptidyl Peptidase VIII human

recombinant, expressed in Sf9 cells

• Código UNSPSC: 12352204
• NACRES: NA.54

Propiedades

• Nivel de calidad: 200
• recombinante: expressed in Sf9 cells
• Formulario: solution
• actividad específica: ≥20 units/μg protein
• mol peso: 100 kDa
• concentración: ≥0.08 mg/mL
• Condiciones de envío: dry ice
• temp. de almacenamiento: −70°C

Descripción

Aplicación

Human dipeptidyl peptidase VIII has been used in a study to identify ERGIC-53 as an intracellular transport receptor of α1-antitrypsin. Human dipeptidyl peptidase VIII has also been used in a study to investigate the cargo selectivity of the ERGIC-53/MCFD2 transport receptor complex.

Acciones bioquímicas o fisiológicas

Dipeptidyl peptidase VIII (DPP8) is a 100 kDa monomeric protein expressed in the cytoplasm. It is a postproline dipeptidyl aminopeptidase that is homologous to DPPIV and fibroblast activation protein (FAP). It hydrolyzes Ala-Pro, Arg-Pro and Gly-Pro. DPP8 has a neutral pH optimum. It may be involved in T-cell activation and immune function as it is similar to DPPIV . It is upregulated during immune activation.

Propiedades físicas

Full length sequence with an N-terminal GST tag

Definición de unidad

One unit will hydrolyze 1.0 picomole of Ala-Pro-AMC per minute at pH 7.4 at 25 deg °C

Forma física

Supplied as a solution in 40 mM Tris-HCL, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 3 mM DTT and 20% glycerol.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 1