C8742

CHIC-35

≥97% (chiral, HPLC)

• Sinónimos: (6S)-2-Chloro-5,6,7,8,9,10-hexahydro-cyclohept[b]indole-6-carboxamide, Compound (S)-35
• Fórmula empírica (notación de Hill): C₁₄H₁₅ClN₂O
• Número de CAS: 848193-72-6
• Peso molecular: 262.73
• Número MDL: MFCD11045286
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 329775186
• NACRES: NA.77

Propiedades

• Análisis: ≥97% (chiral, HPLC)
• formulario: solid
• solubilidad: DMSO: >10 mg/mL; H₂O: <2 mg/mL
• temp. de almacenamiento: 2-8°C
• cadena SMILES: ClC1=CC=C(NC2=C3CCCC[C@@H]2C(N)=O)C3=C1
• InChI: 1S/C14H15ClN2O/c15-8-5-6-12-11(7-8)9-3-1-2-4-10(14(16)18)13(9)17-12/h5-7,10,17H,1-4H2,(H2,16,18)/t10-/m0/s1
• Clave InChI: ABIVOOWWGYJNLV-JTQLQIEISA-N

Descripción

Acciones bioquímicas o fisiológicas

CHIC-35 is cell-permeable, metabolically stable, and very potent inhibitor of SIRT1; IC₅₀ of S-isomer is 60 nM; IC₅₀ of mixed isomers is 124 nM. There is no inhibition of SIRT3 or HDAC. The IC₅₀ for SIRT2 is 2.77 μM. Sirtuins are protein deacetylases, which represent a new class of histone deacetylases (HDAC) involved in gene silencing. SIRT modulators are potential therapeutics for cancer, diabetes, muscle differentiation, heart failure, neurodegeneration, and aging.

Características y beneficios

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Faceshields, Gloves