C7867

Anti-claspin (C-terminal) antibody produced in mouse

IgG fraction of antiserum, buffered aqueous solution

• Número MDL: MFCD06411798
• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 200
• conjugado: unconjugated
• forma del anticuerpo: IgG fraction of antiserum
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• formulario: buffered aqueous solution
• mol peso: antigen 250 kDa (170 kDa band that may correspond to a claspin related protein is observed in some cell lines)
• reactividad de especies: human
• técnicas: microarray: suitable; western blot: 1:250-1:500 using K562 cell extracts
• Nº de acceso UniProt: Q9HAW4
• Condiciones de envío: dry ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... CLSPN(63967)

Descripción

Inmunógeno

synthetic peptide corresponding to amino acids 1321-1339 of human claspin, conjugated to KLH via an N-terminal added cysteine residue.

Aplicación

Anti-Claspin (C-terminal) antibody is suitable for microarray and western blot analysis at a dilution of 1:250-1:500.

Acciones bioquímicas o fisiológicas

Claspin is a protein which plays a major role in DNA replication. It involves in protecting DNA replication forks against DNA damage. In DNA damage response, claspin directly interacts with Rad17, which is required for ATR activation. ATR is activated by various DNA damage and DNA replication stress. Once activated, ATR (ataxia telangiectasia mutated-Rad3 related protein) phosphorylates effector kinase Chk1 which further depends on mediator protein claspin. Claspin helps to stimulate phosphorylation reaction of Chk1.

Forma física

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)