C6995
Anti-COMT (N-terminal) antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
Sinónimos:
Anti-Catechol-O-methyltransferase
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About This Item
Código UNSPSC:
12352203
NACRES:
NA.41
origen biológico
rabbit
conjugado
unconjugated
forma del anticuerpo
IgG fraction of antiserum
tipo de anticuerpo
primary antibodies
clon
polyclonal
Formulario
buffered aqueous solution
mol peso
antigen ~24 kDa (and ~28 kDa)
reactividad de especies
human, rat, mouse
técnicas
western blot: 1:250-1:500 using whole extracts of mouse and rat liver and HEK-293T cells expressing human COMT
Nº de acceso UniProt
Condiciones de envío
dry ice
temp. de almacenamiento
−20°C
modificación del objetivo postraduccional
unmodified
Información sobre el gen
human ... COMT(1312)
mouse ... Comt1(12846)
rat ... Comt(24267)
Descripción general
The gene Catechol-O-methyltransferase (COMT) is mapped to human chromosome 22q11.2. COMT is also referred to as HEL-S-98n. It is widely expressed in various tissues, including brain, liver, kidney, endometrium and breast.
Especificidad
The antibody recognizes MB-COMT and S-COMT.
Aplicación
Anti-COMT (N-terminal) antibody produced in rabbit has been used in immunoblotting.
Acciones bioquímicas o fisiológicas
Catechol-O-methyltransferase (COMT) is a Mg2+-dependent enzyme. COMT catalyzes transfer of methyl groups from S-adenosyl methionine to catecholamines. It is responsible for degradation of catecholamines and thereby results in psychiatric disorders and symptoms. Met/Met genotype individuals can acquire skill in executive function tasks (as multi-unmanned vehicles supervisory control, to a higher level and/or faster than other genotype groups). On the other hand, COMT polymorphism is linked to major depressive disorder and bipolar disorder. The genetic variants of COMT alter neurobehavioral functions that are affected by mercury in adults and might modify the adverse neurobehavioral effects of mercury exposure in children. COMT polymorphism is associated with high risk of premature ovarian insufficiency. COMT single nucleotide polymorphism preoperative humans psychological status and postoperative opioid analgesia efficacy. COMT acts as a tumor supressor gene for colorectal cancer cell lines. Overexpression of COMT supresses pancreatic cancer.
Forma física
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Producto relacionado
Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
WGK 2
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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Emerson Barchi Cordts et al.
Journal of ovarian research, 7, 47-47 (2014-05-09)
Estrogens are important factors in the female reproductive functions and are processed by a number of enzymes along their metabolic pathway. The COMT gene constitutes a crucial element in estrogen metabolism and is assumed to be involved in the development
Pituitary adenylate cyclase-activating polypeptide (PACAP) has a neuroprotective function in dopamine-based neurodegeneration in rat and snail parkinsonian models
Maasz G, et al.
Disease models & mechanisms, 10(2), 127-139 (2017)
A L Potapov et al.
Anesteziologiia i reanimatologiia, 60(3), 48-51 (2015-09-30)
To evaluate the influence of µl-opioid receptor (OPRM1) 118A>G and catechol-O-methyltransferase (COMT) 1947G>A gene single nucleotide polymorphisms (SNP) combinations on postoperative opioid analgesia (POA) efficacy. In 100 consecutive patients scheduled for major urologic surgeries the SNPs of OPRM1 118A>G and
G Pandolfo et al.
Journal of affective disorders, 177, 108-113 (2015-03-15)
Major depressive disorder (MDD) and bipolar disorder (BD) are the two most common mood disorders. Given the recognized involvement of catecholamines in depression, genetic research focused on the evaluation of polymorphisms in genes coding for proteins that regulate neurotransmitter release
Wenming Wu et al.
Archives of medical research, 46(1), 17-23 (2014-12-24)
Catechol-O-methyltransferase (COMT) has been reported as an important molecule in various types of cancers. The biological function of COMT in colorectal cancer (CRC) has not yet been fully investigated. We constructed a transient transfection of a CRC cell lines to
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