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C5493

Sigma-Aldrich

CyPPA

≥98% (HPLC), solid

Sinónimos:

Cyclohexyl-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-pyrimidin-4-yl]-amine

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About This Item

Fórmula empírica (notación de Hill):
C16H23N5
Número de CAS:
73029-73-9
Peso molecular:
285.39
Número MDL:
MFCD01550586
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
329775087
NACRES:
NA.77

Nivel de calidad

100

Análisis

≥98% (HPLC)

formulario

solid

color

white

solubilidad

DMSO: >10 mg/mL
H2O: <2 mg/mL

temp. de almacenamiento

2-8°C

cadena SMILES

Cc1cc(NC2CCCCC2)nc(n1)-n3nc(C)cc3C

InChI

1S/C16H23N5/c1-11-10-15(18-14-7-5-4-6-8-14)19-16(17-11)21-13(3)9-12(2)20-21/h9-10,14H,4-8H2,1-3H3,(H,17,18,19)

Clave InChI

USEMRPYUFJNFQN-UHFFFAOYSA-N

Aplicación

CyPPA has been used:
  • to test its inhibitory functionality on melanogenesis
  • as an activator of small conductance potassium channel-3 (SK3) in mesenteric artery segments
  • in the activation of calcium-activated potassium (SK) channels in murine hippocampal neurons HT-22 cells

Acciones bioquímicas o fisiológicas

CyPPA is a positive modulator of small conductance Ca2+-activated K+ channels; selective for SK3 and SK2. CyPPA is a first subtype selective SK channel positive modulator with an EC50 of 5.6 μM and 14 μM, efficacy 90% and 71% for hSK3 and hSK2, respectively. CyPPA is a tool for distinguishing SK2 and SK3 from SK1 and IK; no other agents distinguish these channels.

Características y beneficios

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictogramas

Exclamation mark
GHS07

Palabra de señalización

Warning

Frases de peligro

H315,H319,H335,H413

Clasificaciones de peligro

Aquatic Chronic 4 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Órganos de actuación

Respiratory system

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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SK channel activation modulates mitochondrial respiration and attenuates neuronal HT-22 cell damage induced by H2O2
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