C5105
Anti-Calcium Channel (α2/δ-1 Subunit) antibody produced in rabbit
affinity isolated antibody, lyophilized powder
Sinónimos:
Anti-CACNA2, Anti-CACNL2A, Anti-CCHL2A, Anti-LINC01112, Anti-lncRNA-N3
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About This Item
Productos recomendados
origen biológico
rabbit
Nivel de calidad
conjugado
unconjugated
forma del anticuerpo
affinity isolated antibody
tipo de anticuerpo
primary antibodies
clon
polyclonal
Formulario
lyophilized powder
reactividad de especies
mouse, rat, pig, human
técnicas
western blot (chemiluminescent): 1:200 using rat brain membranes
Nº de acceso UniProt
temp. de almacenamiento
−20°C
modificación del objetivo postraduccional
unmodified
Información sobre el gen
human ... CACNA2D1(781)
mouse ... Cacna2d1(12293)
rat ... Cacna2d1(25399)
Categorías relacionadas
Descripción general
CACNA2D1 (calcium channel, voltage-dependent, α2/δ subunit 1) is a member of a family of GPI-anchored voltage-gated calcium channels (VGCCs)-associated subunits called α2δ. VGCC are composed of three types of subunits- pore-forming α1 and auxiliary β and α2δ subunits.
Inmunógeno
synthetic peptide corresponding to amino acids 1-15 of α2 subunit (amino acids 27-41 of rabbit α2/δ−1 precursor).
Aplicación
Anti-Calcium Channel (α2/δ-1 Subunit) antibody produced in rabbit has been used in immunoblotting and immunofluorescence.
Acciones bioquímicas o fisiológicas
CACNA2D1 (calcium channel, voltage-dependent, α2/δsubunit 1) is a type of α2δs, which are involved in the synaptic neurotransmitter release as they are concentrated at the synapses. They have a chaperone-like activity in non-neuronal cells. This protein acts as a target for gabapentin, which is a neuropathic analgesic. Mutations in this gene, in humans result in short QT syndrome (SQTS).
Descripción de destino
L-type of Voltage-gated Ca2+ Channel.
Forma física
Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin, and 0.05% sodium azide.
Nota de preparación
Reconstitute the 0.05 mL vial with 50 μL deionized water. Reconstitute the 0.2 mL vial with 0.2 mL deionized water. After reconstitution, the antibody concentration is ~0.8 mg/mL.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Opcional
Referencia del producto
Descripción
Precios
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 2
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Yuki Domon et al.
The Journal of pharmacology and experimental therapeutics, 365(3), 573-582 (2018-03-23)
Mirogabalin ([(1R,5S,6S)-6-(aminomethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl]acetic acid), a novel ligand for the α2δ subunit of voltage-gated calcium channels, is being developed to treat pain associated with diabetic peripheral neuropathy and postherpetic neuralgia. In the present study, we investigated the in vitro binding characteristics and
Macroglia-derived thrombospondin 2 regulates alterations of presynaptic proteins of retinal neurons following elevated hydrostatic pressure
Wang S, et al.
Testing, 12(9), e0185388-e0185388 (2017)
K Brickley et al.
FEBS letters, 364(2), 129-133 (1995-05-08)
Polyclonal antibodies were raised against peptides corresponding to residues 1-15, 469-483 and 933-951 of the rabbit skeletal muscle L-type calcium channel alpha 2/delta primary translation product, for use as topological probes. Immunocytochemical comparison of the abilities of the antibodies to
Transcription Factor Sp1 Regulates the Expression of Calcium Channel $\alpha$2$\delta$-1 Subunit in Neuropathic Pain
Gomez k, et al.
Neuroscience, 12(9), e0185388-e0185388 (2019)
The alpha 2 delta-1-NMDA receptor coupling is essential for corticostriatal long-term potentiation and is involved in learning and memory
Zhou J, et al.
The Journal of Biological Chemistry, 293(50), 19354-19364 (2018)
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