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Key Documents

C3865

Sigma-Aldrich

Anti-N-Cadherin antibody, Mouse monoclonal

clone GC-4, purified from hybridoma cell culture

Sinónimos:

Anti-A-CAM, Anti-A-Cell Adhesion Molecule

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About This Item

Número MDL:
Código UNSPSC:
12352203
NACRES:
NA.41

origen biológico

mouse

Nivel de calidad

conjugado

unconjugated

forma del anticuerpo

purified immunoglobulin

tipo de anticuerpo

primary antibodies

clon

GC-4, monoclonal

formulario

buffered aqueous solution

mol peso

antigen 135 kDa

reactividad de especies

chicken, monkey, mouse, human, rabbit, rat

técnicas

electron microscopy: suitable
flow cytometry: suitable
immunocytochemistry: suitable
immunohistochemistry: 10-20 μg/mL using rat cardiac muscle frozen sections
western blot: 10-20 μg/mL using chicken cardiac muscle or COS-7 cell extracts

isotipo

IgG1

Nº de acceso UniProt

aplicaciones

research pathology

Condiciones de envío

dry ice

temp. de almacenamiento

−20°C

modificación del objetivo postraduccional

unmodified

Información sobre el gen

human ... CDH2(1000)
mouse ... Cdh2(12558)
rat ... Cdh2(83501)

Descripción general

N-Cadherin is a member of the cadherin family of proteins that mediate cell-cell adhesion in a calcium dependent manner. N-cadherin is a transmembrane glycoprotein that localizes in the cell-cell adherens junction on the plasma membrane. The protein is known to be localized in the cell membrane.

Aplicación

Anti-N-Cadherin antibody is suitable for the following procedures:
  • electron microscopy
  • flow cytometry
  • immunocytochemistry
  • immunohistochemistry at a concentration of 10-20μg/mL using rat cardiac muscle frozen sections
  • western blot at a concentration of 10-20μg/mL using chicken cardiac muscle or COS-7 cell extracts

Acciones bioquímicas o fisiológicas

CDH11 gene encodes a type II classical cadherin that mediate calcium-dependent cell-cell adhesion.
Higher expression of CDH2 gene was observed in tumor cells. It is known to induce the invasive and chemoresistant attributes to the cancer cells. N-glycosylation of N-cadherin is associated with the process of tumorigenesis especially in mammary gland, renal system, and ovary. Loss of expression of the gene was observed in adrenocortical carcinoma.

Forma física

0.2 μm-filtered solution in 0.01 M phosphate buffered saline, pH 7.4.

Otras notas

Clone GC-4 is also known as GB-9.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Opcional

Referencia del producto
Descripción
Precios

Código de clase de almacenamiento

12 - Non Combustible Liquids

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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In several types of cancers, tumor cells invade adjacent tissues by migrating along the resident nerves of the tumor microenvironment. This process, called perineural invasion, typically occurs along extrinsic nerves, with Schwann cells providing physical guidance for the tumor cells.
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Mechanisms of acute pain transition to chronic pain are not fully understood. Here we demonstrate an active role of β-arrestin 2 (Arrb2) in regulating spinal cord NMDA receptor (NMDAR) function and the duration of pain. Intrathecal injection of the mu-opioid
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Journal of Cellular Biochemistry, 118(8), 2064-2071 (2017)
Chemotherapy enriches for an invasive triple-negative breast tumor cell subpopulation expressing a precursor form of N-cadherin on the cell surface.
Nelson ER, et al.
Oncotarget, 7(51), 84030-84030 (2016)

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