C2499

CP-339818

≥98% (HPLC)

• Sinónimos: N-[1-(phenylmethyl)-4(1H)-quinolinylidene]-1-pentanamine hydrochloride
• Fórmula empírica (notación de Hill): C₂₁H₂₄N₂ · HCl
• Número de CAS: 478341-55-8
• Peso molecular: 340.89
• Número MDL: MFCD09878238
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 329775008
• NACRES: NA.77

Propiedades

• Análisis: ≥98% (HPLC)
• formulario: powder
• color: white to off-white
• solubilidad: DMSO: >10 mg/mL
• emisor: Wyeth
• temp. de almacenamiento: 2-8°C
• cadena SMILES: Cl.CCCCC\N=C1/C=CN(Cc2ccccc2)c3ccccc13
• InChI: 1S/C21H24N2.ClH/c1-2-3-9-15-22-20-14-16-23(17-18-10-5-4-6-11-18)21-13-8-7-12-19(20)21;/h4-8,10-14,16H,2-3,9,15,17H2,1H3;1H/b22-20+;
• Clave InChI: JIRISCAPZWLWCG-QPNALZDCSA-N

Descripción

Acciones bioquímicas o fisiológicas

CP-338818 blocks both Kv1.3 and Kv1.4. Kv1.3 is expressed in brain and in effector memory T (Tem) cells, and Kv1.4 is expressed in brain cells. Kv1.3 and Kv1.4 are members of the Shaker family of voltage-gated potassium channels. Both channels are involved in setting the membrane potential of neurons. In addition, Kv1.3 maintains the membrane potential for T memory cells and is up-regulated upon T cell activation, contributing to multiple immune processes and disorders. Blockers of Kv1.3 have long been sought for therapeutic benefit, and they are also valuable tools for studying the immune system. CP-339818 is valuable for immune system studies, where the absence of Kv1.4 makes it functionally selective for Kv1.3, and it has shown suppression of T cell activation. CP-339818 is also valuable for the study of Kv1.4 function.

Características y beneficios

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Wyeth. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable