C1649
Cardiolipina solution from bovine heart
4.7-5.3 mg/mL in ethanol, ≥97% (TLC)
Sinónimos:
Diphosphatidylglycerol solution
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About This Item
Productos recomendados
origen biológico
bovine heart
Nivel de calidad
Ensayo
≥97% (TLC)
Formulario
liquid
envase
glass bottle of
concentración
4.7-5.3 mg/mL in ethanol
color
colorless to yellow
aplicaciones
general analytical
lipidomics
metabolomics
grupo funcional
phospholipid
tipo de lípido
phosphoglycerides
Condiciones de envío
dry ice
temp. de almacenamiento
−20°C
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Descripción general
Cardiolipin (CL) is a complex lipid with a dimeric structure. It has four acyl chains and two phosphatidyl moieties. Its phosphatidyl moieties are linked to the glycerol backbone. Around 15-20 percent of the inner mitochondrial membrane accounts for cardiolipin.
Cardiolipin is a unique phospholipid found exclusively within the mitochondrial inner membrane. This specific localization allows Cardiolipin to exert crucial influence on mitochondrial structure and function. Deviations in Cardiolipin content, structure, or localization can lead to impaired mitochondrial activity, contributing to various diseases like cancer, neurological disorders, cardiovascular conditions, and metabolic diseases. As Cardiolipin plays a crucial role in mitochondrial function, it holds immense potential for biomarker development and finds application in cardiovascular, neuroscience, cancer, diabetes, and metabolomics research.
Aplicación
Cardiolipin solution from bovine heart has been used:
- for coating Corning 96-well enzyme immunoassay/radioimmunoassay (EIA/RIA) plate to perform enzyme-linked immunosorbent assay (ELISA)-based cardiolipin binding assay
- in lipid analysis along with phosphatidylglycerol (PG) to comigrate the radiolabeled lipids to identify PG and cardiolipin (CL)
- in coating ELISA plates for antiphospholipid antibodies (aPL) assays
Acciones bioquímicas o fisiológicas
La cardiolipina es un fosfolípido mitocondrial que se encuentra a bajas concentraciones en los tejidos de los mamíferos. A menudo es un componente de membrana y puede inhibir la unión celular de fibronectina, vitronectina y colágeno tipo I.
Cardiolipin (CL) plays a key role in mitochondrial biogenesis, fusion and fission, respiration, and protein import. It participates in the cellular processes outside of the mitochondria like cell wall biogenesis, aging, vacuole homeostasis, the cell cycle, and apoptosis. CL is also involved in heart function, autophagy/mitophagy, and the protein kinase C (PKC) pathway.
Características y beneficios
- High-quality molecule suitable for mulitple research applications
- Commonly employed in Metabolomics and Biochemical studies
Otras notas
>80% polyunsaturated fatty acid content, primarily linoleic acid.
For additional information on our range of Biochemicals, please complete this form.
Forma física
Approximately 5 mg/ml in ethanol.
Palabra de señalización
Danger
Frases de peligro
Consejos de prudencia
Clasificaciones de peligro
Eye Irrit. 2 - Flam. Liq. 2
Código de clase de almacenamiento
3 - Flammable liquids
Clase de riesgo para el agua (WGK)
WGK 2
Punto de inflamabilidad (°F)
55.4 °F - closed cup
Punto de inflamabilidad (°C)
13 °C - closed cup
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H A Schenkein et al.
Journal of dental research, 92(9), 814-818 (2013-07-17)
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