C1480
Z-Phe-Ala fluoromethyl ketone
≥90% (TLC), powder
Sinónimos:
Z-FA-FMK
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About This Item
Fórmula lineal:
C21H23N2O4F
Peso molecular:
386.42
Número MDL:
Código UNSPSC:
12352209
ID de la sustancia en PubChem:
NACRES:
NA.77
Productos recomendados
Nivel de calidad
Ensayo
≥90% (TLC)
Formulario
powder
color
white to off-white
solubilidad
DMSO or DMF: 20 mM
Condiciones de envío
dry ice
temp. de almacenamiento
−20°C
cadena SMILES
C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc2ccccc2)C(=O)CF
InChI
1S/C21H23FN2O4/c1-15(19(25)13-22)23-20(26)18(12-16-8-4-2-5-9-16)24-21(27)28-14-17-10-6-3-7-11-17/h2-11,15,18H,12-14H2,1H3,(H,23,26)(H,24,27)/t15-,18-/m0/s1
Clave InChI
ASXVEBPEZMSPHB-YJBOKZPZSA-N
Aplicación
Z-Phe-Ala fluoromethyl ketone (Z-FA-FMK) has been used as a:
- cathepsin inhibitor to study its effects on dendritic cells
- papain-like cysteine protease inhibitor to study its effects on cadmium-induced mitochondrial apoptosis
- cysteine protease inhibitor to study its effects on the interaction of toll-like receptor 9 (TLR9) with granulin in RAW macrophages
Acciones bioquímicas o fisiológicas
Z-Phe-Ala fluoromethyl ketone (Z-FA-FMK) is an inhibitor of cysteine proteases, such as cathepsin B and L. It can also inhibit recombinant effector caspases 2, -3, -6, and -7 and not initiator caspases 8 and -10. Z-FA-FMK plays a role in blocking nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) transactivation. It exhibits therapeutic effects against rheumatoid arthritis.
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, type N95 (US)
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