C0493

Monoclonal Anti-Calcium Sensing Receptor from mouse

clone HL1499 (6D4-3F4-6C4), purified from hybridoma cell culture

• Sinónimos: Anti-CAR, Anti-EIG8, Anti-FHH, Anti-FIH, Anti-GPRC2A, Anti-HHC, Anti-HHC1, Anti-HYPOC1, Anti-NSHPT, Anti-PCAR1, Anti-hCasR
• Número MDL: MFCD02262635
• Código UNSPSC: 12352203
• NACRES: NA.41
• conjugado: unconjugated
• application: ELISA (i); ICC; IHC (p); WB
• clon: HL1499 (6D4-3F4-6C4), monoclonal
• reactividad de especies: rabbit, rat, mouse, human
• citations: 10
• técnicas: immunocytochemistry: suitable; immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable; indirect ELISA: suitable; western blot: 3-6 μg/mL using total extract from rat kidney

Propiedades

• origen biológico: mouse
• Nivel de calidad: 200
• conjugado: unconjugated
• forma del anticuerpo: purified immunoglobulin
• tipo de anticuerpo: primary antibodies
• clon: HL1499 (6D4-3F4-6C4), monoclonal
• Formulario: buffered aqueous solution
• reactividad de especies: rabbit, rat, mouse, human
• técnicas: immunocytochemistry: suitable; immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable; indirect ELISA: suitable; western blot: 3-6 μg/mL using total extract from rat kidney
• isotipo: IgG1
• Nº de acceso UniProt: P41180
• Condiciones de envío: dry ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... CASR(846) ; mouse ... Casr(12374) ; rat ... Casr(24247)

Descripción

Descripción general

The calcium sensing receptor (CASR) gene with 11 exons is mapped to human chromosome 3q13.33-q21.1. CASR is a member of the C family of G protein–coupled receptors and is mainly localized in the parathyroid gland and the thick ascending limb of the Henle loop. CASR is a 1078 amino acid protein.

Inmunógeno

peptide corresponding to amino-acids 15-29 at the extracellular N-terminus of calcium sensing receptor.

Aplicación

Monoclonal Anti-Calcium Sensing Receptor antibody produced in mouse is suitable for the following applications:

• Indirect ELISA
• Immunoblotting
• Immunocytochemistry
• Immunohistochemistry (formalin-fixed, paraffin-embedded sections)
• Western blotting at a concentration of 3-6μg/mL using total extract from rat kidney

Monoclonal anti-calcium sensing receptor antibody produced in mouse has been used in western blotting and immunohistochemistry.

Acciones bioquímicas o fisiológicas

Calcium sensing receptor (CASR) regulates cell activity according to the extracellular calcium concentration. It also plays a major role in controlling parathyroid hormone (PTH) secretion. Thus, this protein can be considered as a potent target for therapeutic agents designed to modify parathyroid gland function. CASR has a role in key signal transduction pathways in several tissues such as parathyroid gland, kidney, gastrointestinal tract, placenta, pancreas and brain. Mutation in the gene is associated with autosomal dominant hypocalcemic, hypercalciuria and Bartter syndrome.

Forma física

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable