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Merck

C0434

Sigma-Aldrich

Chorionic gonadotropin human

lyophilized powder, from human pregnancy urine

Sinónimos:

Choriogonin, HCG

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About This Item

Número de CAS:
Número CE:
Número MDL:
Código UNSPSC:
12352209
NACRES:
NA.32

origen biológico

human pregnancy urine

Nivel de calidad

esterilidad

sterile-filtered

formulario

lyophilized powder

potencia

~13,000 I.U. per mg

mol peso

37.9 kDa

impurezas

HBsAg, HCV and HIV-1/HIV-2, tested negative

solubilidad

water: 2 mg/mL, clear, colorless

Nº de acceso UniProt

Condiciones de envío

ambient

temp. de almacenamiento

−20°C

Información sobre el gen

human ... CGA(1081)

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Descripción general

Glycoprotein hormone consisting of a 92-amino acid α-chain which is identical to that of LH, FSH, and TSH; and a distinct 149-amino acid β-chain. Produced by chorionic tissue and responsible for maintaining the corpus luteum during early pregnancy. Also produced by trophoblast cell neoplasms, which are marked by elevated free hCG β-chains and hyperglycosylated hCG.

Acciones bioquímicas o fisiológicas

Human chorionic gondadotropin (hCG) may be used as an alternative to PMSG to induce ovulation in laboratory animals. When hCG was injected into laboratory animals via intravenous (i.v.), intraperitoneal (i.p.), or subcutaneous (s.c.) methodstet, the effective dose values for 50% of the animals (ED50) per animal and per body weight (kg) in parenthesis were as follows:
Mice: i.v. 0.2 (7.7) I.U.; i.p. 0.3 (11.5) I.U.; s.c. 0.7 (26.9) I.U.
Syrian hamsters: i.v. 1.0 (9.5) I.U.; i.p. 1.8 (17.1) I.U.; s.c. 2.6 (24.8) I.U.
Rats: i.v. 1.3 (4.6) I.U.; i.p. 3.5 (12.3) I.U.; s.c.7.5 (26.3) I.U.

Using PMSG, the ED50 values per animal and per body weight (kg) in parenthesis were as follows:
Mice: i.v. 0.8 (30.8) I.U.; i.p. 2.0 (76.9) I.U.; s.c. 2.8 (107.7) I.U
Syrian hamsters: i.v., 3.6 (34.3) I.U.; i. p., 8.0 (76.2) I.U.; s.c., 13.2 (125.7) I.U.
Rats: i.v., 6.0 (76.8) I.U.; i p., 20.8 (73.0) I.U.; s.c., 76.8 (269.5) I.U.

Ligadura / enlace

Similar to C2047, but from a different supplier.

Pictogramas

Health hazard

Palabra de señalización

Warning

Frases de peligro

Consejos de prudencia

Clasificaciones de peligro

Repr. 2

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


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