B3313

Bicyclol

≥98% (HPLC)

• Sinónimos: 4, 4′-dimethoxy-2, 3, 2′, 3′-bis(methylenedioxy)-6-hydroxymethyl-6′-methoxy-carbonyl biphenyl
• Fórmula empírica (notación de Hill): C₁₉H₁₈O₉
• Número de CAS: 118159-48-1
• Peso molecular: 390.34
• Número MDL: MFCD00889471
• Código UNSPSC: 12352202
• ID de la sustancia en PubChem: 329773215
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥98% (HPLC)
• Formulario: powder
• condiciones de almacenamiento: desiccated
• color: white to off-white
• solubilidad: DMSO: >10 mg/mL
• temp. de almacenamiento: 2-8°C
• cadena SMILES: COC(=O)c1cc(OC)c2OCOc2c1-c3c(CO)cc(OC)c4OCOc34
• InChI: 1S/C19H18O9/c1-22-11-4-9(6-20)13(17-15(11)25-7-27-17)14-10(19(21)24-3)5-12(23-2)16-18(14)28-8-26-16/h4-5,20H,6-8H2,1-3H3
• Clave InChI: KXMTXZACPVCDMH-UHFFFAOYSA-N

Descripción

Descripción general

Bicyclol has anti-inflammatory properties and enhances the prognosis of kidney transplantation. It is involved in the removal of reactive oxygen species and modulates cytokine secretion.

Acciones bioquímicas o fisiológicas

Bicyclol is a anti-hepatitis drug, used in China for chronic hepatitis B and presumably C. The drug appears to protect against liver injury in animals. Recently it was reported that bicyclol induce the expression of hepatic HSP27 and HSP70, and thus consequently inhibits the transcription factor NF-?B-mediated apoptosis and necrosis in liver tissue. It appears that bicyclol induces hepatic HSP27 and HSP70 expression through activating transcription of HSPs genes.

Información de seguridad

• Pictogramas: GHS09
• Palabra de señalización: Warning
• Frases de peligro: H410
• Consejos de prudencia: P273 - P391 - P501
• Clasificaciones de peligro: Aquatic Acute 1 - Aquatic Chronic 1
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Gloves