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B1434

Sigma-Aldrich

Bone Morphogenetic Protein 7 human

>95% (SDS-PAGE), recombinant, expressed in CHO cells, lyophilized powder, suitable for cell culture

Sinónimos:

BMP-7, OP-1, Osteogenic protein 1

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About This Item

Número MDL:
MFCD03702812
Código UNSPSC:
12352202
NACRES:
NA.32

origen biológico

human

Nivel de calidad

100

recombinante

expressed in CHO cells

Análisis

>95% (SDS-PAGE)

formulario

lyophilized powder

potencia

0.2-0.6 μg/mL ED50

mol peso

monomer calculated mol wt 15.7 kDa
 18-20 kDa by SDS-PAGE (reducing)
 30-40 kDa by SDS-PAGE (non-reducing)

envase

pkg of 10 μg

condiciones de almacenamiento

avoid repeated freeze/thaw cycles (Do not store in a frost-free freezer.)

técnicas

cell culture | mammalian: suitable

impurezas

endotoxin, tested

Nº de acceso UniProt

P18075

temp. de almacenamiento

−20°C

Información sobre el gen

human ... BMP7(655)

Acciones bioquímicas o fisiológicas

Cellular responses to BMP-7 are mediated by the formation of hetero-oligomeric complexes of type I and II serine/threonine kinase receptors. Human and mouse BMP-7 share 98% amino acid sequence identity.

Forma física

Lyophilized from 50.0 μl of a 0.2 μm filtered solution in 35% acetonitrile, 0.1% TFA containing 50 μg bovine serum albumin per 1μg of cytokine.

Nota de análisis

The biological activity is measured by its ability to induce alkaline phosphatase production using mouse ATDC-5 chondrogenic cells.

Pictogramas

Exclamation mark
GHS07

Palabra de señalización

Warning

Frases de peligro

H315,H319

Clasificaciones de peligro

Eye Irrit. 2 - Skin Irrit. 2

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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A J Celeste et al.
Proceedings of the National Academy of Sciences of the United States of America, 87(24), 9843-9847 (1990-12-01)
Characterization of the polypeptides present in bone-inductive protein extracts from bovine bone has led to the cloning of seven regulatory molecules, six of which are distantly related to transforming growth factor beta. The three human bone morphogenetic proteins (BMPs) we
A H Reddi
Nature biotechnology, 16(3), 247-252 (1998-04-07)
Morphogenesis is the developmental cascade of pattern formation and body plan establishment, culminating in the adult form. It has formed the basis for the emerging discipline of tissue engineering, which uses principles of molecular developmental biology and morphogenesis gleaned through
Yan Wang et al.
Experimental and molecular pathology, 98(3), 393-402 (2015-03-17)
This study presented the effect of bone morphogenic protein-7 (BMP-7) inhibiting epithelial-mesenchymal transition (EMT) in silicosis model. In vivo, Wistar rats were exposed to silica by intratracheal instillation. Seven days later rats were treated with BMP-7. Rats were sacrificed at
Endre Kristóf et al.
Scientific reports, 5, 12540-12540 (2015-07-28)
Laser-scanning cytometry is presented as a tool allowing population scale analysis of ex vivo human brown adipogenic differentiation. It combines texture analysis and detection of Ucp1 protein content in single brown adipocytes of mixed cell populations with gene expression pattern
Pilar González-Gómez et al.
Oncotarget, 6(13), 10950-10963 (2015-04-11)
Glioblastoma tumor initiating cells are believed to be the main drivers behind tumor recurrence, and therefore therapies that specifically manage this population are of great medical interest. In a previous work, we synthesized controlled release microspheres optimized for intracranial delivery
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