AV46122

Anti-HIST1H1C antibody produced in rabbit

affinity isolated antibody

• Sinónimos: Anti-H1.2, Anti-H1F2, Anti-Histone cluster 1, H1c, Anti-MGC3992
• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• conjugado: unconjugated
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• Formulario: buffered aqueous solution
• mol peso: 21 kDa
• reactividad de especies: human
• concentración: 0.5 mg - 1 mg/mL
• técnicas: ChIP: suitable; western blot: suitable
• Nº de acceso NCBI: NP_005310
• Nº de acceso UniProt: P16403
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• Información sobre el gen: human ... HIST1H1C(3006)

Descripción

Descripción general

Histone H1 proteins are linker histones that interacts with linker DNA between nucleosomes to compact chromatin into higher order structures. There are multiple histone one genes in the histone 1 cluster that produce histone 1 variants. Histone cluster 1, H1c (HIST1H1C) is the H1C variant of histone 1 that is differentially expressed by cells.

Especificidad

Anti-HIST1H1C polyclonal antibody reacts with human, mouse, rat, chicken, and pig H1c variants of histone 1 proteins.

Inmunógeno

Synthetic peptide directed towards the middle region of human HIST1H1C

Aplicación

Anti-HIST1H1C polyclonal antibody is used to tag the H1c variant of histone 1 for detection and quantitation by Western blotting and in plasma by immunohistochemical (IHC) techniques. It is used as a probe to determine the differential expression of histone 1, H1c versus other histone 1 proteins during cell differentiation.

Acciones bioquímicas o fisiológicas

Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures.Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Secuencia

Synthetic peptide located within the following region: ASGSFKLNKKAASGEAKPKVKKAGGTKPKKPVGAAKKPKKAAGGATPKKS

Forma física

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable