AV45599

Anti-NR3C2 antibody produced in rabbit

IgG fraction of antiserum

• Sinónimos: Anti-MCR, Anti-MGC133092, Anti-MLR, Anti-MR, Anti-Nuclear receptor subfamily 3, group C, member 2
• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• conjugado: unconjugated
• forma del anticuerpo: IgG fraction of antiserum
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• Formulario: buffered aqueous solution
• mol peso: 107 kDa
• reactividad de especies: human, rabbit
• concentración: 0.5 mg - 1 mg/mL
• técnicas: immunohistochemistry: suitable; western blot: suitable
• Nº de acceso NCBI: NP_000892
• Nº de acceso UniProt: P08235
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... NR3C2(4306)

Descripción

Descripción general

Mineralocorticoid receptor/nuclear receptor subfamily 3, group C, member 2/ (NR3C2, MLR, MCR) is a nuclear receptor for mineralocorticoids (eg. aldosterone) and glucocorticoids (eg. cortisol) that activates expression of proteins involved with ionic (salt balance) and water transport such as the epithelial sodium channel, Na+/K+ pump and serum and glucocorticoid induced kinase (SGK1).

Especificidad

Anti-NR3C2 polyclonal antibody reacts with chicken, human, mouse, and rat mineralocorticoid/ aldosterone receptors.

Inmunógeno

Synthetic peptide directed towards the middle region of human NR3C2

Aplicación

Anti-NR3C2 polyclonal antibody is used to tag mineralocorticoid receptor protein for detection and quantitation by Western blotting and in plasma by immunohistochemical (IHC) techniques. It is used as a probe to determine the roles of mineralocorticoid receptor in the mineralocorticoid and glucocorticoid ligand-dependent control of salt balance and water retention.

Acciones bioquímicas o fisiológicas

NR3C2 is a receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. It binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels.

Secuencia

Synthetic peptide located within the following region: RRKNCPACRLQKCLQAGMNLGARKSKKLGKLKGIHEEQPQQQQPPPPPPP

Forma física

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable