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Merck
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Key Documents

AV44108

Sigma-Aldrich

Anti-SLC15A4 antibody produced in rabbit

affinity isolated antibody

Sinónimos:

Anti-FP12591, Anti-PHT1, Anti-PTR4, Anti-Solute carrier family 15, member 4

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

origen biológico

rabbit

Nivel de calidad

100

conjugado

unconjugated

forma del anticuerpo

affinity isolated antibody

tipo de anticuerpo

primary antibodies

clon

polyclonal

formulario

buffered aqueous solution

mol peso

62 kDa

reactividad de especies

human

concentración

0.5 mg - 1 mg/mL

técnicas

immunohistochemistry: suitable
western blot: suitable

Nº de acceso NCBI

NP_663623

Nº de acceso UniProt

Q8N697

Condiciones de envío

wet ice

temp. de almacenamiento

−20°C

modificación del objetivo postraduccional

unmodified

Información sobre el gen

human ... SLC15A4(121260)

Inmunógeno

Synthetic peptide directed towards the N terminal region of human SLC15A4

Aplicación

Anti-SLC15A4 antibody produced in rabbit is suitable for western blotting at a concentration of 0.25μg/ml and for immunohistochemistry of paraffin-embedded tissue sections at a concentration of 4-8μg/ml.

Acciones bioquímicas o fisiológicas

SLC15A4 (PHT1; PTR4) is a peptide/histidine transporter expressed in the brain and the retina. This protein enables plasmacytoid dendritic cells to sense toll-like receptor ligands that aid in triggering immune responses to persistent viral infections. The expression of SLC15A4 has been implicated in the pathogenesis of lupus.

Secuencia

Synthetic peptide located within the following region: MEGSGGGAGERAPLLGARRAAAAAAAAGAFAGRRAACGAVLLTELLERAA

Forma física

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Amanda L Blasius et al.
PLoS pathogens, 8(9), e1002915-e1002915 (2012-10-03)
Plasmacytoid dendritic cells (pDCs) are the major producers of type I IFN in response to viral infection and have been shown to direct both innate and adaptive immune responses in vitro. However, in vivo evidence for their role in viral
T Yamashita et al.
The Journal of biological chemistry, 272(15), 10205-10211 (1997-04-11)
Here we report the cloning and functional characterization of a rat novel peptide/histidine transporter (PHT1), which was expressed in the brain and the retina. The cDNA encodes the predicted protein of 572 amino acid residues with 12 putative membrane-spanning domains.
Roberto Baccala et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(8), 2940-2945 (2013-02-06)
In vitro evidence suggests that plasmacytoid dendritic cells (pDCs) are intimately involved in the pathogenesis of lupus. However, it remains to be determined whether these cells are required in vivo for disease development, and whether their contribution is restricted to

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