AV41643
Anti-AGER (AB2) antibody produced in rabbit
IgG fraction of antiserum
Sinónimos:
Anti-Advanced glycosylation end product-specific receptor, Anti-MGC22357, Anti-RAGE
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About This Item
Productos recomendados
origen biológico
rabbit
Nivel de calidad
conjugado
unconjugated
forma del anticuerpo
IgG fraction of antiserum
tipo de anticuerpo
primary antibodies
clon
polyclonal
formulario
buffered aqueous solution
mol peso
38 kDa
reactividad de especies
human
concentración
0.5 mg - 1 mg/mL
técnicas
immunohistochemistry: suitable
western blot: suitable
Nº de acceso NCBI
Nº de acceso UniProt
Condiciones de envío
wet ice
temp. de almacenamiento
−20°C
modificación del objetivo postraduccional
glycosylation
Información sobre el gen
human ... AGER(177)
Descripción general
The receptor for advanced glycation end products (RAGE or AGER), a member of the immunoglobulin superfamily, is involved in pathologies such as atherosclerosis, micro- and macrovascular diseases, inflammatory diseases and diabetes. RAGE binds advanced glycation end products (AGE) produced by non-enzymatic glycation or glyoxidation of proteins, lipids and nucleic acids.
The previously assigned protein identifier A2BFI7 has been merged into Q15109. Full details can be found on the UniProt database.
The previously assigned protein identifier A2BFI7 has been merged into Q15109. Full details can be found on the UniProt database.
Especificidad
Anti-RAGE (AB2) polyclonal antibody reacts with human advanced glycosylation end product-specific receptor (AGER).
Inmunógeno
Synthetic peptide directed towards the C terminal region of human AGER
Aplicación
Anti-AGER (AB2) polyclonal antibody is used to tag advanced glycation end product receptor protein(s) for detection and quantitation by Western blotting and in cells and tissues by immunohistochemical (IHC) techniques. Anti-AGER (AB2) polyclonal antibody may be used to study the effects/roles of glycation and glyoxidation in cardiovascular disease and diabetes.
Acciones bioquímicas o fisiológicas
AGER mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. It is receptor for amyloid beta peptide.This gene encodes a member of the immunoglobulin superfamily of cell surface molecules. It is a receptor for various molecules, including the amyloidogenic form of serum amyloid A, amyloid-beta protein, members of the S100/calgranulin superfamily and advanced glycation end products. The gene lies within the major histocompatibility complex (MHC) class III region on chromosome 6. Alternative splicing results in two transcript variants encoding different isoforms.
Secuencia
Synthetic peptide located within the following region: RIRAGNSSPGPGDPGRPGDSRPAHWGHLVAKAATPRRGEEGPRKPGGRGG
Forma física
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
¿Ya tiene este producto?
Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
Jae-Chul Lee et al.
Neurochemical research, 39(8), 1553-1563 (2014-06-02)
The receptor for advanced glycation end products (RAGE) is a multi-ligand receptor of the immunoglobulin superfamily that has been implicated in multiple neuronal and inflammatory stress processes. In this study, we examined changes in RAGE immunoreactivity and its protein levels
Rongzhen Jiang et al.
Journal of immunology (Baltimore, Md. : 1950), 193(10), 5000-5012 (2014-10-24)
High mobility group box 1 (HMGB1) plays an important role in the pathologic processes of endothelial permeability under oxidative stress. Trophoblast oxidative stress has been implicated in the pathophysiology of preeclampsia (PE). HMGB1 serum levels are increased in PE. However
Anisuzzaman et al.
The Journal of clinical investigation, 124(10), 4429-4444 (2014-11-18)
Ticks are notorious hematophagous ectoparasites and vectors of many deadly pathogens. As an effective vector, ticks must break the strong barrier provided by the skin of their host during feeding, and their saliva contains a complex mixture of bioactive molecules
Julia Ranzinger et al.
Cell and tissue research, 357(3), 667-679 (2014-05-30)
The receptor for advanced glycation end-products (RAGE), a multiligand receptor of the immunoglobulin superfamily, takes part in various inflammatory processes. The role of this receptor in the context of intercellular communication, like nanotube (NT)-mediated interaction, is largely unknown. Here, we
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