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Merck
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AV100871

Sigma-Aldrich

Anti-TCF3 (AB2) antibody produced in rabbit

IgG fraction of antiserum

Sinónimos:

Anti-E2A, Anti-ITF1, Anti-MGC129647, Anti-MGC129648, Anti-Transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41
conjugado:
unconjugated
application:
WB
clon:
polyclonal
reactividad de especies:
mouse, dog, guinea pig, human, rat
citations:
3
técnicas:
western blot: suitable

origen biológico

rabbit

Nivel de calidad

100

conjugado

unconjugated

forma del anticuerpo

IgG fraction of antiserum

tipo de anticuerpo

primary antibodies

clon

polyclonal

Formulario

buffered aqueous solution

mol peso

48 kDa

reactividad de especies

mouse, dog, guinea pig, human, rat

concentración

0.5 mg - 1 mg/mL

técnicas

western blot: suitable

Nº de acceso NCBI

NP_003191

Nº de acceso UniProt

P15923

Condiciones de envío

wet ice

temp. de almacenamiento

−20°C

modificación del objetivo postraduccional

unmodified

Información sobre el gen

human ... TCF3(6929)

Inmunógeno

Synthetic peptide directed towards the C terminal region of human TCF3

Aplicación

Anti-TCF3 antibody produced in rabbit is suitable for western blotting at a concentration of 5 μg/ml.

Acciones bioquímicas o fisiológicas

TCF3 belongs to the E-protein (class I) family of transcription factors and is an important regulator of B and T lymphocyte development, tumor growth and progression. TCF3 modulates the Wnt-mediated signaling and regulates osteogenesis and neural differentiation.

Secuencia

Synthetic peptide located within the following region: EENTSAADHSEEEKKELKAPRARTSPDEDEDDLLPPEQKAEREKERRVAN

Forma física

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
QC0871

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Michal Slyper et al.
Cancer research, 72(21), 5613-5624 (2012-10-24)
Regulatory factors controlling stem cell identity and self-renewal are often active in aggressive cancers and are thought to promote their growth and progression. TCF3 (also known as TCF7L1) is a member of the TCF/LEF transcription factor family that is central
W Liu et al.
Cell death & disease, 4, e539-e539 (2013-03-16)
Wnt signaling pathways are a highly conserved pathway, which plays an important role from the embryonic development to bone formation. The effect of Wnt pathway on osteogenesis relies on their cellular environment and the expression of target genes. However, the
Yaser Atlasi et al.
PLoS genetics, 9(5), e1003424-e1003424 (2013-05-10)
Canonical Wnt signaling plays a rate-limiting role in regulating self-renewal and differentiation in mouse embryonic stem cells (ESCs). We have previously shown that mutation in the Apc (adenomatous polyposis coli) tumor suppressor gene constitutively activates Wnt signaling in ESCs and
Atsushi Kuwahara et al.
PloS one, 9(5), e94408-e94408 (2014-05-17)
During mouse neocortical development, the Wnt-β-catenin signaling pathway plays essential roles in various phenomena including neuronal differentiation and proliferation of neural precursor cells (NPCs). Production of the appropriate number of neurons without depletion of the NPC population requires precise regulation

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

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