ABK0018

AfliBridge ELISA

• Código UNSPSC: 41116158
• NACRES: NA.84

Propiedades

• forma del anticuerpo: purified antibody
• Nivel de calidad: 100
• reactividad de especies: mouse, human
• Condiciones de envío: wet ice
• temp. de almacenamiento: 2-8°C

Descripción

Descripción general

A Protein Conformational Array (PCA) in a sandwich ELISA format where the plate is coated with a panel of antibodies raised against peptides derived from the full-length protein sequence of Aflibercept. Taken individually, each of these antibodies is strongly antigenic to the peptide sequence that was used in its production. However, when these peptides are incorporated into a full length correctly folded protein, the antigenicity of many of them is masked by the three-dimensional structure of the protein and only a limited number of the antibodies respond. The result is a histogram which can be likened to a ‘fingerprint′ for correctly folded Aflibercept. For a Eylea Biosimilar, if the protein is correctly folded and glycosylated, the ‘fingerprint′ will match that of Aflibercept. If it is not correctly folded, previously masked peptide sequences will be exposed and will be recognized by the antibody made to that exposed sequence. In this way, changes in the ‘fingerprint′ generated by the ELISA will point out differences between the Biosimilar and authentic Aflibercept.

Aplicación

For research use only. Not for use in diagnostic procedures.

Otras notas

ELISA kit contains 3 96-well microplates and all the components necessary to complete an ELISA test.

Información de seguridad

• Pictogramas: GHS05
• Palabra de señalización: Warning
• Frases de peligro: H290,H315,H319
• Consejos de prudencia: P234 - P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313
• Clasificaciones de peligro: Eye Irrit. 2 - Met. Corr. 1 - Skin Irrit. 2
• Código de clase de almacenamiento: 8B - Non-combustible corrosive hazardous materials
• Clase de riesgo para el agua (WGK): WGK 2