A9935
Anti-Human IgM (μ-chain specific)−Agarose antibody produced in goat
affinity isolated antibody, PBS suspension
Sinónimos:
Anti Human IgM Antibody - Anti-Human IgM (μ-chain specific)-Agarose antibody produced in goat, Anti Human Igm Antibody
Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización
About This Item
Productos recomendados
origen biológico
goat
conjugado
agarose conjugate
forma del anticuerpo
affinity isolated antibody
tipo de anticuerpo
secondary antibodies
clon
polyclonal
formulario
PBS suspension
técnicas
Ouchterlony double diffusion: suitable
immunoelectrophoresis: suitable
capacidad
2-3 mg/mL, resin binding capacity (human IgM)
temp. de almacenamiento
2-8°C
modificación del objetivo postraduccional
unmodified
Descripción general
Goat polyclonal anti-Human IgM (μ-chain specific)−Agarose antibody specific for human IgM when tested against purified human IgA, IgG, IgM, and kappa and lambda light chains. No reactivity with mouse or rat IgG is observed by Ouchterlony Double Diffusion (ODD), prior to agarose bead coupling.
IgM is a highly conserved antibody in vertebrates and is expressed early during immune response. It exists as a pentamer and is secreted by peritoneal B cells.
Immunoglobulin M (IgM) antibodies appear early in the course of infections. IgM antibodies are responsible for agglutination of red blood cells in mis-matched blood transfusions. The level of IgM may vary with the status of disease or infection.
Cyanogen bromide activated cross-linked beaded agarose is frequently conjugated to proteins such as immunoglobulins to facilitate their use in physicochemical processes such as precipitation, absorption and clarification.
Cyanogen bromide activated cross-linked beaded agarose is frequently conjugated to proteins such as immunoglobulins to facilitate their use in physicochemical processes such as precipitation, absorption and clarification.
Aplicación
Anti-Human IgM (μ-chain specific)−Agarose antibody produced in goat has been used in affinity chromatography purification of human IgM.
Goat polyclonal anti-Human IgM (μ-chain specific)−Agarose antibody conjugate is used as an immuno-adsorbent to affinity purify antibodies, to remove species specific cross-reacting antibodies or to remove contaminating antibodies from an antiserum preparation. It has been used for IgM depletion from normal human serum from fasted patients.
Acciones bioquímicas o fisiológicas
IgM plays a key role in the engulfing of apoptotic cells. A reduction in serum IgM levels leads to increased autoimmune response and higher risk for infections. IgM displays polyreactive and autoreactive functionality. It plays a key role in tissue homeostasis by mediating clearance of tissue based molecules. IgM has sites for N-linked glycosylation, with sugars namely, mannose, galactose, N-acetyl glucosamine and sialic acid. IgM linked agarose resins have been tested for efficient conjugate binding.
Otras notas
Antibody adsorbed with mouse and rat IgG
Forma física
Suspension in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Not finding the right product?
Try our Herramienta de selección de productos.
Código de clase de almacenamiento
12 - Non Combustible Liquids
Clase de riesgo para el agua (WGK)
nwg
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
¿Ya tiene este producto?
Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
Los clientes también vieron
Ashfaq Ghumra et al.
PLoS pathogens, 8(4), e1002665-e1002665 (2012-04-26)
Sequence diversity in pathogen antigens is an obstacle to the development of interventions against many infectious diseases. In malaria caused by Plasmodium falciparum, the PfEMP1 family of variant surface antigens encoded by var genes are adhesion molecules that play a
Rina F Villar et al.
Scientific reports, 6, 36298-36298 (2016-11-01)
Activation of immune cells (but not B cells) with lectins is widely known. We used the structurally defined interaction between influenza hemagglutinin (HA) and its cell surface receptor sialic acid (SA) to identify a B cell receptor (BCR) activation modality
S Kløverpris et al.
Molecular human reproduction, 19(11), 756-763 (2013-06-28)
Pregnancy-associated plasma protein-A (PAPP-A) and PAPP-A2, two homologous metzincin metalloproteases, are both tightly linked to regulation within the insulin-like growth factor (IGF) system because of their specific cleavage of IGF binding proteins. Recent studies suggest that PAPP-A may be involved
Rationally designed mimotope library for profiling of the human IgM repertoire
Pashov AD, et al.
bioRxiv, 308973-308973 (2018)
F Magurano et al.
Clinical and diagnostic laboratory immunology, 6(1), 55-60 (1999-01-05)
The Toscana virus (family Bunyaviridae, genus Phlebovirus) is the only sandfly-transmitted virus that demonstrates neurotropic activity. Clinical cases ranging from aseptic meningitis to meningoencephalitis caused by Toscana virus are yearly observed in central Italy during the summer, and several cases
Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.
Póngase en contacto con el Servicio técnico