A8674

Antimycin A from Streptomyces sp.

• Sinónimos: Antipiricullin
• Número de CAS: 1397-94-0
• Número MDL: MFCD01779723
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 24891355
• NACRES: NA.77

Propiedades

• formulario: powder
• Nivel de calidad: 300
• espectro de actividad antibiótica: fungi
• Modo de acción: enzyme | inhibits
• temp. de almacenamiento: −20°C
• cadena SMILES: [H]C(=O)Nc1cccc(C(=O)N[C@H]2[C@@H](C)OC(=O)C(CCCCCC)[C@@H](OC(=O)CC(C)C)[C@H](C)OC2=O)c1O
• InChI: 1S/C28H40N2O9/c1-6-7-8-9-11-20-25(39-22(32)14-16(2)3)18(5)38-28(36)23(17(4)37-27(20)35)30-26(34)19-12-10-13-21(24(19)33)29-15-31/h10,12-13,15-18,20,23,25,33H,6-9,11,14H2,1-5H3,(H,29,31)(H,30,34)/t17-,18+,20?,23+,25+/m1/s1
• Clave InChI: UIFFUZWRFRDZJC-RBVQMQRASA-N

Descripción

Descripción general

Antimycin is an antibiotic produced by Streptomyces species. It inhibits mitochondrial electron transport chain complex III and favors reactive oxygen species (ROS) production, impairing mitochondrial depolarization. It inhibits nitric oxide-mediated apoptosis and modulatescytochrome C release. It suppresses tumorigenesis in lung cancer cells and could be a potential therapeutic agent.Antimycin A serves as a positive control for superoxide generation.

Chemical structure: peptide

Aplicación

Antimycin A from Streptomyces sp. has been used:

• as a respiratory chain inhibitor in neuronal cultures
• in organello ATP production assay in Trypanosoma brucei cells
• in respiration assay for papillary thyroid carcinoma (PTC) cell lines

Antimycin A has been used to study the specific sites of reactive oxygen species production in mitochondria isolated from skeletal muscle of chronic obstructive pulmonary disease patients, and its relationship with local oxidative stress induced by exercise

Acciones bioquímicas o fisiológicas

Inhibitor of electron transfer at complex III. Induces apoptosis.

Calidad

A mixture of antimycins.

Otras notas

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Información de seguridad

• Pictogramas: GHS06,GHS09
• Palabra de señalización: Danger
• Frases de peligro: H300,H400
• Consejos de prudencia: P264 - P273 - P301 + P310 - P391 - P405 - P501
• Clasificaciones de peligro: Acute Tox. 2 Oral - Aquatic Acute 1
• Código de clase de almacenamiento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges