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A7232

Sigma-Aldrich

AP-18

≥98% (HPLC), solid

Sinónimos:

4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime

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About This Item

Fórmula empírica (notación de Hill):
C11H12ClNO
Número de CAS:
55224-94-7
Peso molecular:
209.67
Número MDL:
MFCD00102250
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
329770922
NACRES:
NA.77

Ensayo

≥98% (HPLC)

Formulario

solid

color

white to off-white

solubilidad

DMSO: >10 mg/mL

temp. de almacenamiento

2-8°C

cadena SMILES

CC(=C/c1ccc(Cl)cc1)\C(C)=N\O

InChI

1S/C11H12ClNO/c1-8(9(2)13-14)7-10-3-5-11(12)6-4-10/h3-7,14H,1-2H3/b8-7+,13-9+

Clave InChI

MHTJEUOFLVQMCL-NJHPPEEMSA-N

Aplicación

AP-18 is a selective TRPA1 channel blocker. AP-18 blocks the transient receptor potential ankyrin 1 receptors and can reduce chronic pain associated with arthritis. AP-18 reduces cinnamaldehyde-induced nociception in vivo and blocks cold- and mustard oil-induced activation of mouse TRPA1 but not capsaicin-induced activation. AP-18 reverses CFA-induced mechanical hyperalgesia in mice

Acciones bioquímicas o fisiológicas

AP-18 is a selective TRPA1 channel blocker.
AP-18 is a selective TRPA1 channel blocker. Transient receptor potential A1 (TRPA1) plays a central role for chemical sensing in the pain pathway. AP-18 is a novel TRPA1 channel blocker. It reduces cinnamaldehyde-induced nociception in vivo and blocks cold- and mustard oil-induced activation of mouse TRPA1 but not capsaicin-induced activation demonstrating selectivity vs. TRPV11. AP-18 reverses CFA-induced mechanical hyperalgesia in mice.

Pictogramas

Exclamation mark
GHS07

Palabra de señalización

Warning

Frases de peligro

H302

Clasificaciones de peligro

Acute Tox. 4 Oral

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
BGBC5537
103M4601V
110M4621V
068K46134
068K46133

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Chen Chen et al.
Cell biology international, 34(3), 293-299 (2009-12-02)
Adipocyte lines are a useful tool for adipocyte research. Recently, a new preadipocyte line designated AP-18 was established from subcutaneous tissue of the C3H/He mouse. In this study, we further characterized AP-18 cells. Adipocyte differentiation was assessed by accumulation of
Daisuke Sugiyama et al.
Anesthesiology, 127(4), 695-708 (2017-06-24)
H2O2 has a variety of actions in skin wounds but has been rarely studied in deep muscle tissue. Based on response to the transient receptor potential ankyrin 1 antagonists after plantar incision, we hypothesized that H2O2 exerts nociceptive effects via
Puja Saluja et al.
Antonie van Leeuwenhoek, 101(4), 733-742 (2011-12-28)
Four yeast strains (APSS 805, APSS 806, APSS 815 and AP-18) belonging to a novel Torulaspora species were isolated from coal mine soils of Singareni in Andhra Pradesh state, India. Another strain (PBA-22) was isolated from agricultural field soil from
Elizabeth S Fernandes et al.
Arthritis and rheumatism, 63(3), 819-829 (2011-03-02)
To investigate the involvement of transient receptor potential ankyrin 1 (TRPA1) in inflammatory hyperalgesia mediated by tumor necrosis factor α(TNFα) and joint inflammation. Mechanical hyperalgesia was assessed in CD1 mice, mice lacking functional TRP vanilloid 1 (TRPV1-/-) or TRPA1 (TRPA1-/-)
Takashi Miyamoto et al.
PloS one, 4(10), e7596-e7596 (2009-11-07)
Nitric oxide (NO) can induce acute pain in humans and plays an important role in pain sensitization caused by inflammation and injury in animal models. There is evidence that NO acts both in the central nervous system via a cyclic
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