A4941

Activin A human

≥95% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, lyophilized powder, suitable for cell culture

• Sinónimos: Activin A Protein, Growth Factor, Human Growth Factor
• Número CE: 201-069-1
• Número MDL: MFCD02685750
• Código UNSPSC: 12352202
• NACRES: NA.32

Propiedades

• product name: Activin A human, ≥95% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, lyophilized powder, suitable for cell culture
• origen biológico: human
• Nivel de calidad: 200
• recombinante: expressed in baculovirus infected insect cells
• Análisis: ≥95% (SDS-PAGE)
• formulario: lyophilized powder
• potencia: 1-10 ng/mL ED₅₀
• mol peso: dimer 26 kDa (containing 116 amino acid residues βA subunits)
• envase: pkg of 10 μg; pkg of 5 μg
• técnicas: cell culture | mammalian: suitable
• impurezas: endotoxin, tested
• Nº de acceso UniProt: P08476
• temp. de almacenamiento: −20°C
• Información sobre el gen: human ... INHBA(3624)

Descripción

Descripción general

Activin A gene with two exons is mapped to human chromosome 2q35. Activin A also known as inhibin α-subunit belongs to the TGF-β (transforming growth factor-β) superfamily of proteins and its expression is exclusive to gonads, placenta and adrenal cortex.

Aplicación

Activin A human has been used as a constituent of modified barth′s saline used in in vitro induction of pronephros. It has also been used as a constituent of Roswell Park memorial institute (RPMI) media to induce pancreatic differentiation of multipotent dermal fibroblasts in vitro.

Acciones bioquímicas o fisiológicas

Activins play a vital role in the regulation of hormonogenesis, cellular homeostasis and differentiation programs. Elevated expression of activin A and B leads to the loss of muscle mass. Both activin A and B have a potential to act as a serum markers of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME).

Forma física

Lyophilized from 0.2 μm filtered solution in 10 mM sodium citrate, pH 3.0.

Nota de análisis

The biological activity is determined by its ability to inhibit the proliferation of mouse MPC-11 cells.

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H319,H335
• Consejos de prudencia: P261 - P264 - P271 - P280 - P304 + P340 + P312 - P305 + P351 + P338
• Clasificaciones de peligro: Eye Irrit. 2 - STOT SE 3
• Órganos de actuación: Respiratory system
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable