A1824

N-Acetyl-5-hydroxytryptamine

≥99% (HPLC), powder, antioxidant

• Sinónimos: N-Acetylserotonin, Normelatonin
• Fórmula empírica (notación de Hill): C₁₂H₁₄N₂O₂
• Número de CAS: 1210-83-9
• Peso molecular: 218.25
• Número CE: 214-916-5
• Número MDL: MFCD00005656
• Código UNSPSC: 12352209
• ID de la sustancia en PubChem: 24278209
• NACRES: NA.32

Propiedades

• product name: N-Acetyl-5-hydroxytryptamine, ≥99% (HPLC), powder
• Nivel de calidad: 200
• Análisis: ≥99% (HPLC)
• formulario: powder
• color: white to faint yellow
• mp: 120-122 °C (lit.)
• solubilidad: ethanol: 50 mg/mL
• temp. de almacenamiento: 2-8°C
• cadena SMILES: CC(=O)NCCc1c[nH]c2ccc(O)cc12
• InChI: 1S/C12H14N2O2/c1-8(15)13-5-4-9-7-14-12-3-2-10(16)6-11(9)12/h2-3,6-7,14,16H,4-5H2,1H3,(H,13,15)
• Clave InChI: MVAWJSIDNICKHF-UHFFFAOYSA-N
• Información sobre el gen: human ... MTNR1A(4543) , MTNR1B(4544)

Descripción

Descripción general

N-Acetylserotonin (NAS)/normelatonin acts as a precursor of melatonin in the tryptophan metabolic pathway.

Aplicación

N-Acetyl-5-hydroxytryptamine has been used to treat neuron cells and to analyze its effects on Krüppel-like factor 15 (KLF15) expression.

Acciones bioquímicas o fisiológicas

N-acetyl-serotonin (NAS/normelatonin) can act as a shelter to neurons due to its protecting ability against oxidative challenges. It can also repress the actions of the transcription factor NF-kappaB. NAS possesses antioxidant and antiaging actions. It has protective action against β-amyloid induced neurotoxicity. It helps to maintain the optimal fluidity of the biological membranes.

Immediate precursor of melatonin. It is formed from serotonin and acetyl-CoA in a reaction catalyzed by serotonin N-acetyl transferase, the rate-limiting enzyme in melatonin biosynthesis. This indoleamine is a weak agonist at melatonin receptors, and has moderate effects on G-protein stimulation and inhibition of cAMP accumulation.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)