A0729
Monoclonal Anti-Activin B antibody produced in mouse
clone 146807, purified immunoglobulin
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About This Item
origen biológico
mouse
Nivel de calidad
conjugado
unconjugated
forma del anticuerpo
purified immunoglobulin
tipo de anticuerpo
primary antibodies
clon
146807, monoclonal
reactividad de especies
human
técnicas
neutralization: 0.6-3.0 μg/mL using Activin B-induced hemoglobin expression in the K562 human chronic myelogenous leukemia cell line. (ND50)
western blot: 1-2 μg/mL
isotipo
IgG1
Nº de acceso UniProt
temp. de almacenamiento
−20°C
modificación del objetivo postraduccional
unmodified
Información sobre el gen
human ... INHBB(3625)
Descripción general
Activins are members of the TGF-β family. Activins are dimeric proteins composed of 2 β subunits. Acitivn B contains 2 β B subunits. Activins bind to the Type II Activin receptor triggering phosphorylation of Type I Acitivn receptor (ALK4) and activation of downstream pathways such as proliferation and apoptosis.
Activins are pleotropic cytokines that belong to the TGF-β superfamily. There are three forms of activin, homodimeric activin A (βA-βA), activin B (βB-βB) and the heterodimeric activin AB (βA-βB). Activins bind to type I (ActRI) or type II (ActRII) receptor complexes. The cellular targets of Activin are Smad-2, -3 and -4 that form hetromeric complex and regulate transcription of target genes. The other pathways mediated by activins are Rho A, MAPK, p38 and JNK pathways. Activins play vital role in regulation of growth, differentiation, erythropoiesis, angiogenesis, survival or neural cells and tissue repair. Activin B is reported to promote wound healing by epithelial cell proliferation and migration via the RhoA-JNK signaling pathway. It is also vital in follicular development during the estrous cycle and normal fertility in female mammals. Various reports indicate the role of activin B in normal function of pancreatic β cells and in reducing the growth of renal cell carcinoma
Monoclonal Anti-Activin B recognizes human activin B.
Monoclonal Anti-Activin B recognizes human activin B.
Inmunógeno
purified, CHO cell-derived, recombinant human activin B.
Aplicación
Anti-Activin B antibody may be used for immunoblotting at a working concentration of 1-2 μg/ml. The recommended working antibody concentration for ELISA is 0.5-1.0 μg/ml. For neutralization of human activin B expressed in K562 cell line, a concentration of 0.6-3.0 μg/ml is recommended.
Forma física
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 5% trehalose
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, type N95 (US)
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
Activin Signaling and Its Role in Regulation of Cell Proliferation, Apoptosis, and Carcinogenesis.
Chen, Y.
The Journal of Experimental Biology, 231, 534-544 (2006)
J M Young et al.
Reproduction (Cambridge, England), 143(5), 637-650 (2012-03-28)
Little is known about the role of activin B during folliculogenesis. This study investigated the expression levels of activin/inhibin subunits (βA, βB, and α), steroid enzyme, and gonadotrophin receptors in theca (TC) and granulosa cells (GC) by QPCR and activin
Yin Xia et al.
The Journal of endocrinology, 202(1), 1-12 (2009-03-11)
Activin was discovered in the 1980s as a gonadal protein that stimulated FSH release from pituitary gonadotropes and was thought of as a reproductive hormone. In the ensuing decades, many additional activities of activin were described and it was found
Ingrid Wacker et al.
Molecular and cellular biology, 29(7), 1707-1718 (2009-01-23)
The von Hippel-Lindau tumor suppressor gene (VHL) is mutated in clear cell renal cell carcinomas (RCC), leading to the activation of hypoxia-inducible factor (HIF)-mediated gene transcription. Several VHL/HIF targets, such as glycolysis, angiogenesis, cell growth, and chemotaxis of tumor cells
Philippe Bertolino et al.
Proceedings of the National Academy of Sciences of the United States of America, 105(20), 7246-7251 (2008-05-16)
All major cell types in pancreatic islets express the transforming growth factor (TGF)-beta superfamily receptor ALK7, but the physiological function of this receptor has been unknown. Mutant mice lacking ALK7 showed normal pancreas organogenesis but developed an age-dependent syndrome involving
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