A0132

Atropine

≥99% (TLC), powder

• Sinónimos: Hyoscyamine, Tropine tropate, endo-(±)-α-(Hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester
• Fórmula empírica (notación de Hill): C₁₇H₂₃NO₃
• Número de CAS: 51-55-8
• Peso molecular: 289.37
• Beilstein: 91260
• Número CE: 200-104-8
• Número MDL: MFCD00022622
• Código UNSPSC: 41116107
• ID de la sustancia en PubChem: 24890401
• NACRES: NA.77

Propiedades

• Ensayo: ≥99% (TLC)
• Formulario: powder
• color: white
• solubilidad: H₂O: 2 mg/mL; dilute aqueous acid: soluble; ethanol: soluble
• cadena SMILES: CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)C(CO)c3ccccc3
• InChI: 1S/C17H23NO3/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12/h2-6,13-16,19H,7-11H2,1H3/t13-,14+,15+,16?
• Clave InChI: RKUNBYITZUJHSG-SPUOUPEWSA-N
• Información sobre el gen: human ... CHRM1(1128) , CHRM2(1129) , CHRM3(1131) , CHRM4(1132) , CHRM5(1133) , LOC730413(730413) ; mouse ... Chrm1(12669) ; rat ... Chrm1(25229) , Chrm2(81645) , Chrm3(24260) , Drd2(24318) , Htr1a(24473)

Descripción

Descripción general

Atropine, a belladonna alkaloid, is an anti-muscarinic drug. It is extracted from Atropa belladonna. Atropine is an anticholinergic agent, which is linked to passive mydriasis. It blocks acetylcholine receptors in brain and has hallucinogenic effects. Atropine eye drops are used to treat uveitis and early amblyopia. It is also used to treat nerve agents.

Aplicación

Atropine has been used to study it′s in vitro cytotoxicity, antiviral and antimicrobial activities. It has also used to antagonize acetylcholine induced K⁺ current.

Atropine has been used:

• as a tastant to analyse the bitter taste perception in Drosophila larvae
• as a muscarinic acetylcholine autoreceptors (mAChRs) antagonist to investigate the involvement of individual mAChR subtypes in the control of synapse elimination
• to investigate the pathways of serotonin (5-HT) action in zebrafish hearts

Acciones bioquímicas o fisiológicas

Atropine is used to treat myopia and ocular axial elongation in Asian children. Small dosage of atropine is used to slow down the heart rate.

Competitive nonselective antagonist at central and peripheral muscarinic acetylcholine receptors.

Características y beneficios

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Reconstitución

Solutions stable for several days at 4 °C.

Información de seguridad

• Pictogramas: GHS06
• Palabra de señalización: Danger
• Frases de peligro: H300 + H330
• Consejos de prudencia: P260 - P264 - P271 - P284 - P304 + P340 + P310 - P403 + P233
• Clasificaciones de peligro: Acute Tox. 2 Inhalation - Acute Tox. 2 Oral
• Código de clase de almacenamiento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges