477R-1

MAGEC2 (EP405) Rabbit Monoclonal Primary Antibody

• Sinónimos: Melanoma-associated antigen C2
• Código UNSPSC: 12352203

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100; 500
• conjugado: unconjugated
• forma del anticuerpo: culture supernatant
• tipo de anticuerpo: primary antibodies
• clon: EP405, monoclonal
• descripción: For In Vitro Diagnostic Use in Select Regions
• formulario: buffered aqueous solution
• reactividad de especies: human
• envase: vial of 0.1 mL concentrate (477R-14); vial of 0.1 mL concentrate Research Use Only (477R-14-RUO); vial of 0.5 mL concentrate (477R-15); vial of 1.0 mL concentrate (477R-16); vial of 1.0 mL concentrate Research Use Only (477R-16-RUO); vial of 1.0 mL pre-dilute Research Use Only (477R-17-RUO); vial of 1.0 mL pre-dilute ready-to-use (477R-17); vial of 7.0 mL pre-dilute ready-to-use (477R-18); vial of 7.0 mL pre-dilute ready-to-use Research Use Only (477R-18-RUO)
• fabricante / nombre comercial: Cell Marque^™
• técnicas: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:50 (concentrated)
• isotipo: IgG
• control: seminoma
• Condiciones de envío: wet ice
• temp. de almacenamiento: 2-8°C
• visualización: nuclear

Descripción

Descripción general

Melanoma-associated antigen C2 (MAGEC2), encoded by the testis cancer gene CT10, belongs to a family of proteins that bind E3 RING ubiquitin ligases via a common MAGE homology domain.^1-3 The MAGE-RING complexes that are formed enhance the activity of the ubiquitin ligase binding partners. In vitro studies suggest that MAGEC2, which binds to TRIM28, is involved in tumorigenesis through the increased degradation of p53.⁴ In germ cell tumors, aberrant expression of MAGEC2 is exhibited in seminomas, but is absent in yolk sac tumor and embryonal carcinoma.^5-7

Calidad

United States - IVD
Canada - RUO
European Union - IVD
Japan - RUO

Forma física

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Nota de preparación

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Otras notas

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Información legal

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): WGK 2