380R-2

Arginase-1 (EP261) Rabbit Monoclonal Primary Antibody

• Código UNSPSC: 12352203

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100; 500
• conjugado: unconjugated
• forma del anticuerpo: culture supernatant
• tipo de anticuerpo: primary antibodies
• clon: EP261, monoclonal
• descripción: For In Vitro Diagnostic Use in Select Regions
• formulario: buffered aqueous solution
• reactividad de especies: human
• envase: vial of 0.1 mL concentrate (380R-24); vial of 0.1 mL concentrate Research Use Only (380R-24-RUO); vial of 0.5 mL concentrate (380R-25); vial of 1.0 mL concentrate (380R-26); vial of 1.0 mL concentrate Research Use Only (380R-26-RUO); vial of 1.0 mL pre-dilute Research Use Only (380R-27-RUO); vial of 1.0 mL pre-dilute ready-to-use (380R-27); vial of 7.0 mL pre-dilute ready-to-use (380R-28); vial of 7.0 mL pre-dilute ready-to-use Research Use Only (380R-28-RUO)
• fabricante / nombre comercial: Cell Marque^™
• técnicas: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:200 (concentrated)
• isotipo: IgG
• control: hepatocellular carcinoma, normal liver
• Condiciones de envío: wet ice
• temp. de almacenamiento: 2-8°C
• visualización: cytoplasmic, nuclear
• Información sobre el gen: human ... ARG1(383)

Descripción

Descripción general

Arginase-1 is a key urea cycle metalloenzyme that has demonstrated expression in normal human liver with a high degree of specificity. Hepatocellular carcinoma (HCC) is the most common primary malignant tumor of the liver accounting for an estimated 70%-85% of total liver cancers worldwide. Diagnostic pitfalls exist in the morphologic distinction of HCC from other hepatocellular and non-hepatocellular lesions. In difficult or equivocal cases, the application of immunohistochemical (IHC) panels has been shown to aid in the distinction of benign and malignant liver lesions. In sections of normal liver, anti-arginase-1 produced strong, diffuse cytoplasmic reactivity in all hepatocytes throughout the lobule. In some cases, patchy nuclear reactivity is also evident in hepatocytes along with the cytoplasmic reactivity. Reactivity is not observed in bile duct epithelial cells, sinusoidal endothelial cells, Kupffer cells, or vascular endothelial cells. In sections of HCC, anti-arginase-1 produces cytoplasmic or cytoplasmic plus nuclear reactivity.

Calidad

IVD

IVD

IVD

RUO

Ligadura / enlace

Arginase-1 Positive Control Slides, Product No. 380S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Forma física

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Nota de preparación

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Otras notas

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Información legal

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable