311R-1

PAX-2 (EP235) Rabbit Monoclonal Primary Antibody

• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100; 500
• conjugado: unconjugated
• forma del anticuerpo: culture supernatant
• tipo de anticuerpo: primary antibodies
• clon: EP235, monoclonal
• descripción: (For In Vitro Diagnostic Use in Select Regions (See Chart))
• Formulario: buffered aqueous solution
• reactividad de especies: human
• envase: bottle of 1.0 mL predilute (311R-17); bottle of 7.0 mL predilute (311R-18); vial of 0.1 mL concentrate (311R-14); vial of 0.5 mL concentrate (311R-15); vial of 1.0 mL concentrate (311R-16)
• fabricante / nombre comercial: Cell Marque^™
• técnicas: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:10-1:50
• isotipo: IgG
• Condiciones de envío: wet ice
• temp. de almacenamiento: 2-8°C
• Información sobre el gen: human ... PAX2(5076)

Descripción

Descripción general

PAX-2 is a homeogene strongly expressed during kidney development. PAX-2 gene is expressed in the metanephric mesenchyma after ureter bud induction and is a key factor for the mesenchyma-epithelium conversion. Animals transgenic for PAX-2 have severe renal abnormalities and cysts but no solid tumoral features. The oncogenic potential of the PAX gene family has been reported <em>in vitro</em> with transformation of cell cultures and <em>in vivo</em> with cell injections in nude mice. Gnarra et al. showed PAX-2 expression in renal carcinoma cell lines and underlined its potential role in cell proliferation in these lines.¹ Mazal et al. demonstrated PAX-2 nuclear expression in 88% of clear cell renal cell carcinomas as well as 18% of papillary renal cell carcinoma, and 13% of chromophobe renal cell carcinomas.² More recently, Chivukula et al. demonstrated utility in distinguishing ovarian serous papillary carcinoma (anti-PAX-2 positive) from breast carcinoma (anti-PAX-2 negative).³

Calidad

IVD

IVD

IVD

RUO

Ligadura / enlace

PAX-2 Positive Control Slides, Product No. 311S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Forma física

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Nota de preparación

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Otras notas

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Información legal

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany