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Merck
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Key Documents

138R-2

Sigma-Aldrich

CD138 (EP201) Rabbit Monoclonal Primary Antibody

clone EP201, unconjugated, Cell Marque™

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

origen biológico

rabbit

Nivel de calidad

100
500

conjugado

unconjugated

forma del anticuerpo

culture supernatant

tipo de anticuerpo

primary antibodies

clon

EP201, monoclonal

descripción

(For In Vitro Diagnostic Use in Select Regions (See Chart))

formulario

buffered aqueous solution

reactividad de especies

human

envase

bottle of 1.0 mL predilute (138R-27)
bottle of 7.0 mL predilute (138R-28)
vial of 0.1 mL concentrate (138R-24)
vial of 0.5 mL concentrate (138R-25)
vial of 1.0 mL concentrate (138R-26)

fabricante / nombre comercial

Cell Marque™

técnicas

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

isotipo

IgG

Condiciones de envío

wet ice

temp. de almacenamiento

2-8°C

Información sobre el gen

human ... SDC1(6382)

Descripción general

CD138, Syndecan 1, is expressed in the late stages of B-cell differentiation with progression towards plasma cells.1,2 It can be used to differentiate lymphoplasmacytic lymphoma from marginal zone lymphoma.1 ALK+ large B-cell lyphoma (LBCL) usually strongly expresses CD138 whereas lineage-associated markers such as anti-CD20 and anti-CD79a do not stain ALK+LBCL.3,7 Anti-CD138 is immunoreactive with HHV8-associated primary effusion lymphoma even though the lymphoma cells lack the expression of B-cell markers.5 Anti-CD138 is a good marker to identify and enumerate plasma cells, benign, reactive, or malignant, in bone marrow biopsy specimens.4,6 CD138 is also expressed in epithelial cells.6

Calidad


IVD
IVD
IVD
RUO

Ligadura / enlace

CD138 Positive Control Slides, Product No. 138S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Forma física

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Nota de preparación

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Otras notas

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Información legal

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Código de clase de almacenamiento

12 - Non Combustible Liquids

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Visite la Librería de documentos

WHO classification of tumours of haematopoietic and lymphoid tissues in 2008: an overview.
E Sabattini et al.
Pathologica, 102(3), 83-87 (2010-12-22)
A Sebestyén et al.
British journal of haematology, 104(2), 412-419 (1999-03-02)
Syndecan-1, an important transmembrane heparan sulphate proteoglycan is expressed in distinct stages of differentiation of normal lymphoid cells: in pre-B cells and Ig-producing plasma cells; however, its normal function, or presence in lymphoid malignancies, is still largely unknown. The expression
I B Bayer-Garner et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 14(10), 1052-1058 (2001-10-13)
Syndecan-1 (CD138) mediates myeloma cell adhesion, and loss of syndecan-1 from the cell surface may contribute to myeloma proliferation and dissemination. Flow cytometry analysis of myeloma cells in bone marrow specimens shows heterogeneity in cell surface syndecan-1 expression. It is
Lluís Colomo et al.
The American journal of surgical pathology, 28(6), 736-747 (2004-05-29)
Plasmablastic lymphoma was initially described as a variant of diffuse large B-cell lymphoma (DLBCL) involving the oral cavity of HIV+ patients and characterized by immunoblastic morphology and a plasma cell phenotype. However, other lymphomas may exhibit similar morphologic and immunophenotypic
M Chilosi et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 12(12), 1101-1106 (2000-01-05)
Detection of abnormal numbers and/or distribution of bone marrow (BM) plasma cells (PCs) on trephine biopsies can be important in the differential diagnosis of multiple myeloma (MM) and other PC disorders. A variety of immunohistochemical markers can potentially improve the
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