123R-2

CD23 (EP75) Rabbit Monoclonal Primary Antibody

• Código UNSPSC: 12352203

Propiedades

• origen biológico: rabbit
• conjugado: unconjugated
• forma del anticuerpo: culture supernatant
• tipo de anticuerpo: primary antibodies
• clon: EP75, monoclonal
• descripción: For In Vitro Diagnostic Use in Select Regions
• Formulario: buffered aqueous solution
• reactividad de especies: human
• envase: vial of 0.1 mL concentrate (123R-24); vial of 0.1 mL concentrate Research Use Only (123R-24-RUO); vial of 0.5 mL concentrate (123R-25); vial of 1.0 mL concentrate (123R-26); vial of 1.0 mL concentrate Research Use Only (123R-26-RUO); vial of 1.0 mL pre-dilute Research Use Only (123R-27-RUO); vial of 1.0 mL pre-dilute ready-to-use (123R-27); vial of 7.0 mL pre-dilute ready-to-use (123R-28); vial of 7.0 mL pre-dilute ready-to-use Research Use Only (123R-28-RUO)
• fabricante / nombre comercial: Cell Marque^™
• técnicas: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500 (concentrated)
• isotipo: IgG
• control: chronic lymphocytic leukemia, lymph node, small lymphocytic lymphoma, tonsil
• Condiciones de envío: wet ice
• temp. de almacenamiento: 2-8°C
• visualización: membranous
• Información sobre el gen: human ... FCER2(2208)

Descripción

Descripción general

CD23 antigen is a 45-60 kDa membrane glycoprotein identified as a low affinity receptor for IgE production as well as a receptor for lymphocyte growth factor. CD23 is found in some mature B-cell lymphomas and in Reed-Sternberg cells in Hodgkin disease. Follicular dendritic cells and some activated B-cells within germinal centers express CD23 in high density and mantle zone B-cells are stained weakly. The majority of chronic lymphocytic leukemias/small lymphocytic lymphomas are CD23 positive, whereas mantle cell lymphomas are generally negative, so this marker is useful when applied with other markers to separate the small cell lymphomas. Precursor B and T lymphomas, myeloid neoplasms, and mature T-cell lymphomas are CD23 negative and other small cell lymphomas are occasionally positive. CD23 is also positive on activated mature B-cells expressing IgM or IgD, monocytes/macrophages, follicular dendritic cells, T-cell subsets, eosinophils, Langerhans cells and small lymphocytic lymphoma/chronic lymphocytic leukemia (SLL/CLL).

Calidad

United States - IVD
Canada - IVD
European Union - RUO
Japan - RUO

Ligadura / enlace

CD23 Positive Control Slides, Product No. 123S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Forma física

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Nota de preparación

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Otras notas

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Información legal

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable