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Merck
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Key Documents

120M-8

Sigma-Aldrich

CD20 (L26) Mouse Monoclonal Antibody

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

origen biológico

mouse

Nivel de calidad

100
500

conjugado

unconjugated

forma del anticuerpo

diluted ascites fluid

tipo de anticuerpo

primary antibodies

clon

L26, monoclonal

descripción

For In Vitro Diagnostic Use in Select Regions (See Chart)

formulario

buffered aqueous solution

reactividad de especies

human

envase

vial of 0.1 mL concentrate (120M-84)
vial of 0.5 mL concentrate (120M-85)
bottle of 1.0 mL predilute (120M-87)
vial of 1.0 mL concentrate (120M-86)
bottle of 7.0 mL predilute (120M-88)

fabricante / nombre comercial

Cell Marque™

técnicas

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

isotipo

IgG2aκ

control

tonsil

Condiciones de envío

wet ice

temp. de almacenamiento

2-8°C

visualización

membranous

Información sobre el gen

human ... MS4A1(931)

Descripción general

Anti-CD20 (B-cell Pan) reacts with a membrane antigen that is present in B-cells. This antibody recognizes Reed-Sternberg cells, predominant in Hodgkin′s disease, in a minority of cases. Since no staining of histiocytes or plasma cells has been observed and CD20 has not been detected in T-cell malignancies, it is a very strong marker of B-cell lymphomas. Anti-CD20 does not cross-react with non-hematopoetic neoplasms.

Calidad


IVD
IVD
IVD
RUO

Ligadura / enlace

CD20 Positive Control Slides, Product No. 120S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Forma física

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Nota de preparación

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Otras notas

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Información legal

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Alexandar Tzankov et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 9(4), 1381-1386 (2003-04-10)
Recent evidence has demonstrated that classical Hodgkin lymphoma (cHL) originates from mature germinal center B cells. However, only approximately 25% of cHLs express the classical B-cell marker CD20. There is very little, and controversial, information on the prognostic significance of
A new look at lymphoma immunohistology.
D Y Mason
The American journal of pathology, 128(1), 1-4 (1987-07-01)
F R Davey et al.
The American journal of pathology, 129(1), 54-63 (1987-10-01)
The use of monoclonal and polyclonal antibodies for the immunophenotyping of non-Hodgkin's lymphomas in paraffin-embedded tissue has been limited by the fact that most antigens on lymphoid cells are denatured by histologic fixation, dehydration, and embedment. In this article the
Patrick Browne et al.
American journal of clinical pathology, 120(5), 767-777 (2003-11-12)
Even with routine immunohistochemical evaluation, distinguishing classic Hodgkin lymphoma (CHL) from diffuse large B-cell lymphoma (DLBCL) or anaplastic large cell lymphoma (ALCL) can be difficult. In these cases, the transcription factors (B cell-specific activator protein [BSAP], octamer-binding transcription factor 2
Y Ishii et al.
Clinical and experimental immunology, 58(1), 183-192 (1984-10-01)
Two distinct antigen systems (L26 and L27) specifically expressed in human B lymphocytes were identified using TB2-2B3 (2B3) and T3-5B3 (5B3) monoclonal antibodies, respectively. Whereas L26 antigen defined by 2B3 were rarely expressed on the surface of B cells but

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