Y0001761

Nicorandil

European Pharmacopoeia (EP) Reference Standard

• Sinónimos: 2-(Pyridine-3-carbonylamino)ethyl nitrate, 2-Nicotinamidoethyl nitrate, Ikorel, N-[2-(Nitrooxy)ethyl]-3-pyridinecarboxamide, SG-75, Sigmart, Zynicor
• Fórmula empírica (notación de Hill): C₈H₉N₃O₄
• Número de CAS: 65141-46-0
• Peso molecular: 211.17
• Número MDL: MFCD00186520
• Código UNSPSC: 41116107
• ID de la sustancia en PubChem: 329831558
• NACRES: NA.24

Propiedades

• grado: pharmaceutical primary standard
• familia API: nicorandil
• fabricante / nombre comercial: EDQM
• aplicaciones: pharmaceutical (small molecule)
• formato: neat
• temp. de almacenamiento: −20°C
• cadena SMILES: [O-][N+](=O)OCCNC(=O)c1cccnc1
• InChI: 1S/C8H9N3O4/c12-8(7-2-1-3-9-6-7)10-4-5-15-11(13)14/h1-3,6H,4-5H2,(H,10,12)
• Clave InChI: LBHIOVVIQHSOQN-UHFFFAOYSA-N

Descripción

Descripción general

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicación

Nicorandil EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Acciones bioquímicas o fisiológicas

Nicorandil is a hybrid ATP-sensitive K+ (KATP) channel opener and nicotinamide nitrate NO donor. Nicorandil selectively activates SUR2B- versus SUR2A-containing KATP channels. It enhances endothelial NO synthase expression and protects against ischemic ventricular arrhythmias. By activating potassium channels, and donating nitric oxide to activate the enzyme guanylate cyclase, Nicorandil causes activation of GMP leading to both arterial and venous vasodilatation. Nicorandil is selective for vascular potassium channels, but has no significant action on cardiac contractility and conduction.

Envase

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Otras notas

Sales restrictions may apply.

Información de seguridad

• Pictogramas: GHS02,GHS07
• Palabra de señalización: Danger
• Frases de peligro: H242,H302
• Consejos de prudencia: P210 - P235 - P280 - P301 + P312 - P370 + P378 - P410
• Clasificaciones de peligro: Acute Tox. 4 Oral - Org. Perox. D
• Código de clase de almacenamiento: 5.2 - Organic peroxides and self-reacting hazardous materials
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable