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Y0001295

Spironolactone for system suitability

European Pharmacopoeia (EP) Reference Standard

Sinónimos:

Spironolactone, 4-Pregnen-21-oic acid-17α-ol-3-one-7α-thiol γ-lactone 7-acetate, 7α-(Acetylthio)-17α-hydroxy-3-oxopregn-4-ene-21-carboxylic acid γ-lactone

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About This Item

Fórmula empírica (notación de Hill):
C24H32O4S
Número de CAS:
52-01-7
Peso molecular:
416.57
Número MDL:
MFCD00082250
Código UNSPSC:
41116107
ID de la sustancia en PubChem:
329831347
NACRES:
NA.24

grado

pharmaceutical primary standard

familia API

spironolactone

fabricante / nombre comercial

EDQM

mp

207-208 °C (lit.)

aplicaciones

pharmaceutical (small molecule)

formato

neat

temp. de almacenamiento

2-8°C

cadena SMILES

CC(=O)S[C@@H]1CC2=CC(=O)CC[C@]2(C)[C@H]3CC[C@@]4(C)[C@@H](CC[C@@]45CCC(=O)O5)[C@H]13

InChI

1S/C24H32O4S/c1-14(25)29-19-13-15-12-16(26)4-8-22(15,2)17-5-9-23(3)18(21(17)19)6-10-24(23)11-7-20(27)28-24/h12,17-19,21H,4-11,13H2,1-3H3/t17-,18-,19+,21+,22-,23-,24+/m0/s1

Clave InChI

LXMSZDCAJNLERA-ZHYRCANASA-N

Información sobre el gen

human ... NR3C2(4306)

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Categorías relacionadas

Descripción general

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicación

Spironolactone for system suitability EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Acciones bioquímicas o fisiológicas

Spironolactone is a competitive aldosterone receptor antagonist. Used as potassium sparing diuretic.

Envase

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Otras notas

Sales restrictions may apply.

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Referencia del producto
Descripción
Precios

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Spironolactone, European Pharmacopoeia (EP) Reference Standard

1619006

Spironolactone, United States Pharmacopeia (USP) Reference Standard

1619017

Spironolactone Related Compound A, United States Pharmacopeia (USP) Reference Standard

BP306

Spironolactone, British Pharmacopoeia (BP) Reference Standard

PHR2886

Spironolactone, pharmaceutical secondary standard, certified reference material

PHR2887

Spironolactone Related Compound A, pharmaceutical secondary standard, certified reference material

PHR3135

Spironolactone Related Compound C, pharmaceutical secondary standard, certified reference material

Pictogramas

Health hazard
GHS08

Palabra de señalización

Danger

Frases de peligro

H351 - H360FD - H373

Clasificaciones de peligro

Carc. 2 - Repr. 1B - STOT RE 2

Código de clase de almacenamiento

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number

Lo sentimos, en este momento no disponemos de COAs para este producto en línea.

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Doson Chua et al.
Clinical cardiology, 33(10), 604-608 (2010-10-21)
Spironolactone is used in the treatment of cardiovascular disease, but is contraindicated in renal dysfunction due to the risk of hyperkalemia. It is not known if patients with end-stage renal disease (ESRD) on hemodialysis are at the same risk for
Deepani Rathnayake et al.
Skinmed, 8(6), 328-332 (2011-03-19)
Spironolactone has been used as a potassium-sparing diuretic for more than 30 years. It is a synthetic 17-lactone steroid and primarily acts as an aldosterone antagonist. Since the accidental discovery of its antiandrogenic effects, it has been used in the
Enrico Vizzardi et al.
The American journal of the medical sciences, 347(4), 271-276 (2013-11-08)
The purpose of this study is to evaluate long-term effects of spironolactone, an affordable and widely used aldosterone receptor blocker, in patients with heart failure (HF) and mild or no symptoms. The study is a single-blind, placebo-controlled, blinded endpoint, randomized
Allan Struthers et al.
Clinical cardiology, 31(4), 153-158 (2008-04-12)
Improved understanding of the adverse pharmacological properties of aldosterone has prompted investigation of the clinical benefits of blocking aldosterone at the receptor level. This article reviews the pharmacology, clinical efficacy, and tolerability of the two available blocking agents, spironolactone and
Oscar M P Jolobe
European journal of internal medicine, 24(4), 303-309 (2012-12-19)
The evolution of strategies for the use of spironolactone and its analogue, eplerenone, has, over the years, encompassed favourable modification of the natural history of symptomatic heart failure in subjects with subnormal left ventricular ejection fraction (LVEF), and mitigation of
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