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Y0001290

Honokiol

European Pharmacopoeia (EP) Reference Standard

Sinónimos:

5,3′-Diallyl-2,4′-dihydroxybiphenyl, NSC 293100

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About This Item

Fórmula empírica (notación de Hill):
C18H18O2
Número de CAS:
35354-74-6
Peso molecular:
266.33
Número MDL:
MFCD00016674
Código UNSPSC:
41116107
ID de la sustancia en PubChem:
329831346
NACRES:
NA.24

grado

pharmaceutical primary standard

familia API

honokiol

fabricante / nombre comercial

EDQM

aplicaciones

pharmaceutical (small molecule)

formato

neat

temp. de almacenamiento

−20°C

cadena SMILES

Oc1ccc(cc1CC=C)-c2cc(CC=C)ccc2O

InChI

1S/C18H18O2/c1-3-5-13-7-9-18(20)16(11-13)14-8-10-17(19)15(12-14)6-4-2/h3-4,7-12,19-20H,1-2,5-6H2

Clave InChI

FVYXIJYOAGAUQK-UHFFFAOYSA-N

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Descripción general

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicación

Honokiol EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Acciones bioquímicas o fisiológicas

Honokiol is a natural biphenyl neolignan from magnolia extract. It is antiangiogenic, antitumor, and anxiolytic.

Envase

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Otras notas

Sales restrictions may apply.

Pictogramas

CorrosionEnvironment
GHS05,GHS09

Palabra de señalización

Danger

Frases de peligro

H318,H411

Clasificaciones de peligro

Aquatic Chronic 2 - Eye Dam. 1

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number

Lo sentimos, en este momento no disponemos de COAs para este producto en línea.

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Ankit Kumar et al.
Future medicinal chemistry, 5(7), 809-829 (2013-05-09)
Honokiol (3,5-di-(2-propenyl)-1,1-biphenyl-2,2-diol) is a natural bioactive neolignan isolated from the genus Magnolia. In recent studies, honokiol has been observed to have anti-angiogenic, anticancer, anti-inflammatory, neuroprotective and GABA-modulating properties in vitro and in preclinical models. Honokiol and its analogs target multiple
Wei Tian et al.
Die Pharmazie, 67(10), 811-816 (2012-11-10)
Honokiol is a small-molecule pharmacologically active component which has various medicinal applications. Increasing interest is paid on its multifunctional anti-tumor effects including inducing tumor cell death, anti-angiogenesis, anti-migration and anti-multiple drug resistance. We addressed a brief summary of the anti-tumor
Levi E Fried et al.
Antioxidants & redox signaling, 11(5), 1139-1148 (2009-02-11)
Honokiol is a small-molecule polyphenol isolated from the genus Magnolia. It is accompanied by other related polyphenols, including magnolol, with which it shares certain biologic properties. Recently, honokiol has been found to have antiangiogenic, antiinflammatory, and antitumor properties in preclinical
Ying Ju Chen et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 32(4), 573-580 (2014-01-01)
Proinflammatory cytokine interleukin-1β (IL-1β) stimulates several mediators of cartilage degradation and plays an important role in the pathogenesis of osteoarthritis (OA). Honokiol, a low molecular weight natural product isolated from the Magnolia officinalis, has been shown to possess anti-inflammatory effect.
S Arora et al.
Current molecular medicine, 12(10), 1244-1252 (2012-07-28)
Honokiol (3',5-di-(2-propenyl)-1,1'-biphenyl-2,4'-diol) is a bioactive natural product derived from Magnolia spp. Recent studies have demonstrated anti-inflammatory, anti-angiogenic, anti-oxidative and anticancer properties of honokiol in vitro and in preclinical models. Honokiol targets multiple signaling pathways including nuclear factor kappa B (NF-κB)
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