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Y0001031

Lamotrigine for peak identification

European Pharmacopoeia (EP) Reference Standard

Sinónimos:

Lamotrigine, 6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine, GI 267119X

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About This Item

Fórmula empírica (notación de Hill):
C9H7Cl2N5
Número de CAS:
84057-84-1
Peso molecular:
256.09
Número MDL:
MFCD00865333
Código UNSPSC:
41116107
ID de la sustancia en PubChem:
329831228
NACRES:
NA.24

grado

pharmaceutical primary standard

familia API

lamotrigine

fabricante / nombre comercial

EDQM

aplicaciones

pharmaceutical (small molecule)

formato

neat

temp. de almacenamiento

2-8°C

cadena SMILES

Nc1nnc(c(N)n1)-c2cccc(Cl)c2Cl

InChI

1S/C9H7Cl2N5/c10-5-3-1-2-4(6(5)11)7-8(12)14-9(13)16-15-7/h1-3H,(H4,12,13,14,16)

Clave InChI

PYZRQGJRPPTADH-UHFFFAOYSA-N

Información sobre el gen

human ... SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)

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Descripción general

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicación

Lamotrigine for peak identification EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Acciones bioquímicas o fisiológicas

Anticonvulsant.

Envase

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Otras notas

Sales restrictions may apply.

Producto relacionado

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Descripción
Precios

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Lamotrigine for system suitability, European Pharmacopoeia (EP) Reference Standard

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Lamotrigine, European Pharmacopoeia (EP) Reference Standard

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2,3-Dichlorobenzoic acid, European Pharmacopoeia (EP) Reference Standard

1356778

2,3-Dichlorobenzoic acid, United States Pharmacopeia (USP) Reference Standard

1356790

Lamotrigine Related Compound D, United States Pharmacopeia (USP) Reference Standard

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Lamotrigine Related Compound C, United States Pharmacopeia (USP) Reference Standard

PHR1368

2,3-Dichlorobenzoic acid, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1392

Lamotrigine, Pharmaceutical Secondary Standard; Certified Reference Material

BP1097

Lamotrigine, British Pharmacopoeia (BP) Reference Standard

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Lamotrigine impurity standard, British Pharmacopoeia (BP) Reference Standard

PHR8729

Lamotrigine Related Compound C, certified reference material, pharmaceutical secondary standard

PHR8730

Lamotrigine Related Compound D, certified reference material, pharmaceutical secondary standard

Pictogramas

Skull and crossbones
GHS06

Palabra de señalización

Danger

Frases de peligro

H301

Clasificaciones de peligro

Acute Tox. 3 Oral

Código de clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number

Lo sentimos, en este momento no disponemos de COAs para este producto en línea.

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Crystal T Clark et al.
The American journal of psychiatry, 170(11), 1240-1247 (2013-11-05)
Little information is available on the need for dosage changes for lamotrigine in pregnant women with bipolar disorder. The authors present new data on serial serum levels of lamotrigine in pregnant patients on lamotrigine monotherapy. They also review the epilepsy
Stacey Shim et al.
The Journal of pharmacology and experimental therapeutics, 347(2), 487-496 (2013-08-30)
Carisbamate and lamotrigine are anticonvulsants that act on neuronal voltage-gated sodium channels. Carisbamate has shown antidepressant-like effects in animal models of depression, and lamotrigine is a mood stabilizer with a therapeutic effect in depressive episodes of patients with bipolar disorder.
Shai Sandalon et al.
Experimental eye research, 115, 47-56 (2013-07-03)
Voltage gated sodium channels (Nav), are proposed mediators of neuronal damage in ischemic and excitotoxicity disease models. We evaluated the neuroprotective effects of lamotrigine, a Nav blocker, in the acute and chronic rat ocular hypertension models. Additionally, expression of the
Chaitali Ghosh et al.
Epilepsia, 54(9), 1562-1570 (2013-07-20)
Brain drug bioavailability is regulated by the blood-brain barrier (BBB). It was recently suggested that cytochrome P450 (CYP) enzymes could act in concert with multidrug transporter proteins to regulate drug penetration and distribution into the diseased brain. The possibility that
Allyson K Friedman et al.
Science (New York, N.Y.), 344(6181), 313-319 (2014-04-20)
Typical therapies try to reverse pathogenic mechanisms. Here, we describe treatment effects achieved by enhancing depression-causing mechanisms in ventral tegmental area (VTA) dopamine (DA) neurons. In a social defeat stress model of depression, depressed (susceptible) mice display hyperactivity of VTA
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