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Y0000702

Metolazone for system suitability

European Pharmacopoeia (EP) Reference Standard

Sinónimos:

Metolazone, 7-Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide

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About This Item

Fórmula empírica (notación de Hill):
C16H16ClN3O3S
Número de CAS:
17560-51-9
Peso molecular:
365.83
Número MDL:
MFCD00069304
Código UNSPSC:
41116107
ID de la sustancia en PubChem:
329831105
NACRES:
NA.24

grado

pharmaceutical primary standard

familia API

metolazone

fabricante / nombre comercial

EDQM

aplicaciones

pharmaceutical (small molecule)

formato

neat

temp. de almacenamiento

2-8°C

cadena SMILES

CC1Nc2cc(Cl)c(cc2C(=O)N1c3ccccc3C)S(N)(=O)=O

InChI

1S/C16H16ClN3O3S/c1-9-5-3-4-6-14(9)20-10(2)19-13-8-12(17)15(24(18,22)23)7-11(13)16(20)21/h3-8,10,19H,1-2H3,(H2,18,22,23)

Clave InChI

AQCHWTWZEMGIFD-UHFFFAOYSA-N

Información sobre el gen

human ... SLC12A3(6559)

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Descripción general

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicación

Metolazone for system suitability EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Acciones bioquímicas o fisiológicas

Inhibitor of thiazide-sensitive Na+-Cl- cotransporter; antihypertensive; moderate "loop" diuretic.

Envase

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Otras notas

Sales restrictions may apply.

Producto relacionado

Referencia del producto
Descripción
Precios

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number

Lo sentimos, en este momento no disponemos de COAs para este producto en línea.

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Pre-dosing metolazone with loop diuretic combination regimens.
Raymond A Lorenz et al.
Nephrology nursing journal : journal of the American Nephrology Nurses' Association, 33(1), 78-79 (2006-03-17)
Domenic A Sica
Congestive heart failure (Greenwich, Conn.), 9(2), 100-105 (2003-04-03)
Metolazone is commonly administered in conjunction with a loop diuretic to manage volume overload in patients otherwise resistant to loop diuretic therapy alone. Metolazone is a thiazide-type diuretic that is characterized by slow and sometimes erratic absorption when administered as
Monimoy Banerjee et al.
Biochemical pharmacology, 92(2), 389-402 (2014-09-03)
Human pregnane X receptor (hPXR) regulates the expression of drug-metabolizing enzyme cytochrome P450 3A4 (CYP3A4) and drug transporters such as multidrug-resistance protein 1 (MDR1). PXR can be modulated by small molecules, including Federal Drug Administration (FDA)-approved drugs, thus altering drug
Mohammed I Walash et al.
Luminescence : the journal of biological and chemical luminescence, 29(5), 462-470 (2013-09-03)
A new, specific and sensitive reversed-phase high-performance liquid chromatography method was developed for the simultaneous determination of metolazone (MET) and losartan potassium (LOS). Good chromatographic separation was achieved within 6.0 min on a 150 × 4.6 mm i.d., 5 µm Waters, Ireland
Lucie Nováková et al.
Analytica chimica acta, 853, 647-659 (2014-12-04)
The potential and applicability of UHPSFC-MS/MS for anti-doping screening in urine samples were tested for the first time. For this purpose, a group of 110 doping agents with diverse physicochemical properties was analyzed using two separation techniques, namely UHPLC-MS/MS and
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