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T0800000

Theophylline

Name: Theophylline
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

Sinónimos:

1,3-Dimethylxanthine, 2,6-Dihydroxy-1,3-dimethylpurine, 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione

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About This Item

Fórmula empírica (notación de Hill):

C₇H₈N₄O₂

Número de CAS:

58-55-9

Peso molecular:

180.16

Beilstein:

13463

Número MDL:

MFCD00079619

Código UNSPSC:

41116107

ID de la sustancia en PubChem:

329826623

NACRES:

NA.24

grado

pharmaceutical primary standard

familia API

theophylline

fabricante / nombre comercial

EDQM

aplicaciones

pharmaceutical (small molecule)

formato

neat

temp. de almacenamiento

2-8°C

cadena SMILES

CN1C(=O)N(C)c2[nH]cnc2C1=O

InChI

1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9)

Clave InChI

ZFXYFBGIUFBOJW-UHFFFAOYSA-N

Información sobre el gen

human ... ADORA1(134) , ADORA2A(135) , ADORA2B(136) , ADORA3(140) , PDE3A(5139) , PDE3B(5140) , PDE4A(5141) , PDE4B(5142) , PDE4C(5143) , PDE4D(5144)

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Descripción general

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicación

Theophylline EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Acciones bioquímicas o fisiológicas

Phosphodiesterase inhibitor; diuretic; cardiac stimulant; muscle relaxant; asthma medication.

Envase

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Otras notas

Sales restrictions may apply.

Producto relacionado

Referencia del producto

Descripción

Precios

1653048

1653037

1653026

1653060

BP327

Theophylline, British Pharmacopoeia (BP) Reference Standard

PHR2588

PHR2541

PHR2551

1121038

8-Chlorotheophylline, United States Pharmacopeia (USP) Reference Standard

Pictogramas

GHS06,GHS08

Palabra de señalización

Danger

Frases de peligro

H301,H360D

Consejos de prudencia

P202 - P264 - P280 - P301 + P310 - P405 - P501

Clasificaciones de peligro

Acute Tox. 3 Oral - Repr. 1B

Código de clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Clase de riesgo para el agua (WGK)

WGK 1

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number

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Hemicellulose-based pH-sensitive and biodegradable hydrogel for controlled drug delivery.

Xiao-Feng Sun et al.

Carbohydrate polymers, 92(2), 1357-1366 (2013-02-13)

Hydrogels based on hemicellulose of wheat straw were prepared as a novel carrier for controlled drug delivery. The chemical structure and morphology of the hydrogels were characterised using FT-IR and SEM, respectively. The swelling ratios of the hydrogels were determined

Theophylline for prevention of contrast-induced nephropathy: a systematic review and meta-analysis.

Sean M Bagshaw et al.

Archives of internal medicine, 165(10), 1087-1093 (2005-05-25)

Contrast-induced nephropathy (CIN) is an important cause of declines in kidney function and is related to greater morbidity, health care costs, and mortality. Adenosine has been proposed to contribute to the pathophysiological process of CIN. We performed a systematic review

Are phosphodiesterase 4 inhibitors just more theophylline?

Victoria Boswell-Smith et al.

The Journal of allergy and clinical immunology, 117(6), 1237-1243 (2006-06-06)

Theophylline has been relegated to a second- or even third-line therapy in the treatment of asthma and chronic obstructive pulmonary disease (COPD), behind glucocorticosteroids and beta2-agonists, although recent findings have suggested that theophylline possesses anti-inflammatory and immunomodulatory effects in addition

Modeling the drug release from hydrogel-based matrices.

Diego Caccavo et al.

Molecular pharmaceutics, 12(2), 474-483 (2014-12-17)

In this work the behavior of hydrogel-based matrices, the most widespread systems for oral controlled release of pharmaceuticals, has been mathematically described. In addition, the calculations of the model have been validated against a rich set of experimental data obtained

Differences between the nonselective adenosine receptor antagonists caffeine and theophylline in motor and mood effects: studies using medium to high doses in animal models.

Laura López-Cruz et al.

Behavioural brain research, 270, 213-222 (2014-05-27)

Caffeine and theophylline are methylxanthines that are broadly consumed, sometimes at high doses, and act as minor psychostimulants. Both are nonselective adenosine antagonists for A1 and A2A receptors, which are colocalized with dopamine D1 and D2 receptors in striatal areas.

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