PHR1767

Melatonina

Pharmaceutical Secondary Standard; Certified Reference Material

• Sinónimos: N-Acetil-5-metoxitriptamina
• Fórmula empírica (notación de Hill): C₁₃H₁₆N₂O₂
• Número de CAS: 73-31-4
• Peso molecular: 232.28
• Beilstein: 205542
• Número CE: 200-797-7
• Número MDL: MFCD00005655
• Código UNSPSC: 41116107
• ID de la sustancia en PubChem: 329823599
• NACRES: NA.24

Propiedades

• grado: certified reference material; pharmaceutical secondary standard
• Nivel de calidad: 300
• Agency: traceable to BP 1077; traceable to USP 1380105
• familia API: melatonin
• formulario: solid
• CofA: current certificate can be downloaded
• envase: pkg of 500 mg
• técnicas: HPLC: suitable; gas chromatography (GC): suitable
• mp: 116.5-118 °C (lit.)
• aplicaciones: pharmaceutical (small molecule)
• temp. de almacenamiento: 2-8°C
• cadena SMILES: COc1ccc2[nH]cc(CCNC(C)=O)c2c1
• InChI: 1S/C13H16N2O2/c1-9(16)14-6-5-10-8-15-13-4-3-11(17-2)7-12(10)13/h3-4,7-8,15H,5-6H2,1-2H3,(H,14,16)
• Clave InChI: DRLFMBDRBRZALE-UHFFFAOYSA-N

Descripción

Descripción general

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. It is analyzed using GMP validated instruments as per pharmacopeia monograph methods and is traceable to Unites States Pharmacopeia (USP), European Pharmacopeia (EP), and British Pharmacopeia (BP) primary standards, wherever applicable. It is provided with a comprehensive certificate of analysis (CoA) containing a certified purity value, calculated by the mass balance approach.
All information regarding the use of this CRM can be found on the certificate of analysis.

Melatonin is a methoxyindole compound secreted by the pineal gland in the mammalian brain. It regulates the sleep-wake cycles (circadian rhythm) and also has anti-inflammatory and antioxidant properties.

Aplicación

Melatonin pharmaceutical reference standard may also be used as follows:

• Development and validation of a high-performance liquid chromatography (HPLC) method combined with UV detection to determine melatonin in capsule dosage forms
• Determination of melatonin in dog plasma samples by liquid chromatography-tandem mass spectrometry (LC-MS/MS) method
• Simultaneous electrochemical analysis of melatonin and 5-hydroxytryptophan by poly-(melamine)/poly-(o-aminophenol) modified screen printed electrodes (SPCs) in human urine samples
• Determination of melatonin in pharmaceutical formulations by voltammetric and amperometric methods using carbon black modified glassy carbon electrode
• Electroanalytical determination of melatonin in tablet and human urine samples using a boron-doped diamond electrode and square-wave voltammetry (SWV)
• Development of nanopalladium polymeric nanocomposite modified glassy carbon electrode (GCE) for qualitative and quantitative analyses of melatonin in tablets and human urine samples by square-wave voltammetry
• Liquid chromatography-diode array detection (LC-DAD) of melatonin dose in supplements and also detection of impurities present in supplements by ultra-high-performance liquid chromatography-orbitrap mass spectrometry (UHPLC-orbitrap-MS)

Otras notas

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Nota al pie de página

To see an example of a Certificate of Analysis for this material enter LRAA8251 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Productos recomendados

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable