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Merck

PHR1690

Supelco

Disulfiram

Pharmaceutical Secondary Standard; Certified Reference Material

Sinónimos:

Tetraethylthiuram disulfide, Bis(diethylthiocarbamoyl) disulfide, Bis(diethylthiocarbamyl) disulfide, Disulfiram, TETD

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About This Item

Fórmula lineal:
(C2H5)2NCSS2CSN(C2H5)2
Número de CAS:
Peso molecular:
296.54
Beilstein:
1712560
Número CE:
Número MDL:
Código UNSPSC:
41116107
ID de la sustancia en PubChem:
NACRES:
NA.24

grado

certified reference material
pharmaceutical secondary standard

Nivel de calidad

Agency

traceable to BP 132
traceable to Ph. Eur. D2950000
traceable to USP 1224008

familia API

disulfiram

CofA

current certificate can be downloaded

envase

pkg of 1 g

técnicas

HPLC: suitable
gas chromatography (GC): suitable

mp

69-71 °C (lit.)

aplicaciones

pharmaceutical (small molecule)

Formato

neat

temp. de almacenamiento

2-30°C

cadena SMILES

CCN(CC)C(=S)SSC(=S)N(CC)CC

InChI

1S/C10H20N2S4/c1-5-11(6-2)9(13)15-16-10(14)12(7-3)8-4/h5-8H2,1-4H3

Clave InChI

AUZONCFQVSMFAP-UHFFFAOYSA-N

Información sobre el gen

human ... ALDH2(217)

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Descripción general

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Disulfiram is clinically used in the treatment of chronic alcoholism.

Aplicación

Disulfiram may be used as a pharmaceutical reference standard for the determination of the analyte in biological fluids and pharmaceutical formulations by high performance liquid chromatography and spectrophotometry, respectively.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Alcohol dehydrogenase inhibitor.

Nota de análisis

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Otras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota al pie de página

To see an example of a Certificate of Analysis for this material enter LRAC2079 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Productos recomendados

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Producto relacionado

Referencia del producto
Descripción
Precios

Palabra de señalización

Warning

Frases de peligro

Clasificaciones de peligro

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Skin Sens. 1 - STOT RE 2

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


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Certificados de análisis (COA)

Lot/Batch Number

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Visite la Librería de documentos

Simultaneous determination of disulfiram and two of its dithiocarbamate metabolites in human plasma by reversed-phase liquid chromatography
Masso PD, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 224(3), 457-464 (1981)
Determination of disulfiram and metabolites from biological fluids by high-performance liquid chromatography
Jensen JC, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 181(3-4), 407-416 (1980)
Spectrophotometric determination of methimazole, D-penicillamine, captopril, and disulfiram in pure form and drug formulations
Skowron M and Ciesielski W
Journal of Analytical Chemistry, 66(8), 714-719 (2011)

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