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Merck

PHR1336

Supelco

Nimesulide

Pharmaceutical Secondary Standard; Certified Reference Material

Sinónimos:

Nimesulide, N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide

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About This Item

Fórmula empírica (notación de Hill):
C13H12N2O5S
Número de CAS:
Peso molecular:
308.31
Número CE:
Número MDL:
Código UNSPSC:
41116107
ID de la sustancia en PubChem:
NACRES:
NA.24

grado

certified reference material
pharmaceutical secondary standard

Nivel de calidad

Agency

traceable to Ph. Eur. N0845000

familia API

nimesulide

CofA

current certificate can be downloaded

técnicas

HPLC: suitable
gas chromatography (GC): suitable

aplicaciones

pharmaceutical (small molecule)

formato

neat

temp. de almacenamiento

2-30°C

cadena SMILES

CS(NC1=C(OC2=CC=CC=C2)C=C([N+]([O-])=O)C=C1)(=O)=O

InChI

1S/C13H12N2O5S/c1-21(18,19)14-12-8-7-10(15(16)17)9-13(12)20-11-5-3-2-4-6-11/h2-9,14H,1H3

Clave InChI

HYWYRSMBCFDLJT-UHFFFAOYSA-N

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Descripción general

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Nimesulide is a selective cyclooxygenase-2 (COX-2) inhibitor that can potentially be used as a therapeutic agent for the treatment of inflammatory conditions. It is also a non-steroidal anti-inflammatory drug (NSAID) that possesses analgesic and antipyretic characters.

Aplicación

Nimesulide may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by spectrophotometry and chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Acciones bioquímicas o fisiológicas

Highly selective cyclooxygenase-2 inhibitor.

Nota de análisis

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Otras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota al pie de página

To see an example of a Certificate of Analysis for this material enter LRAA1070 in the slot below. This is an example certificate only and may not be the lot that you receive.

Productos recomendados

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Producto relacionado

Pictogramas

Skull and crossbones

Palabra de señalización

Danger

Frases de peligro

Consejos de prudencia

Clasificaciones de peligro

Acute Tox. 3 Oral

Código de clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


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Certificados de análisis (COA)

Lot/Batch Number

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Visite la Librería de documentos

Development and validation of a reversed-phase liquid chromatographic method for separation and simultaneous determination of COX-2 inhibitors in pharmaceuticals and its application to biological fluids
Nageswara Rao R, et al.
Biomedical Chromatography, 19(5), 362-368 (2005)
Validated HPTLC method for nimesulide and dicyclomine hydrochloride in formulation
Dhaneshwar SR, et al.
Journal of Pharmacy Research, 4(7), 2288-2290 (2011)
Improved high-performance liquid chromatographic assay for nimesulide
Jaworowicz Jr DJ, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 723(1-2), 293-299 (1999)
Determination of nimesulide in pharmaceutical dosage forms by second order derivative UV spectrophotometry
Altinoz S and Dursun OO
Journal of Pharmaceutical and Biomedical Analysis, 22(1), 175-182 (2000)
Development and validation of a novel RP-HPLC method for simultaneous determination of paracetamol, phenylephrine hydrochloride, caffeine, cetirizine and nimesulide in tablet formulation.
Dewani AP, et al.
Arabian Journal of Chemistry, 8(4), 591-598 (2015)

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