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Merck

PHR1319

Supelco

Trichloroethylene

Pharmaceutical Secondary Standard; Certified Reference Material

Sinónimos:

Trichloroethylene, TCE, Trichloroethene

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About This Item

Fórmula lineal:
ClCH=CCl2
Número de CAS:
Peso molecular:
131.39
Beilstein:
1736782
Número MDL:
Código UNSPSC:
41116107
ID de la sustancia en PubChem:

grado

certified reference material
pharmaceutical secondary standard

Nivel de calidad

Agency

traceable to USP 1601827

densidad de vapor

4.5 (vs air)

presión de vapor

61 mmHg ( 20 °C)

CofA

current certificate can be downloaded

temp. de autoignición

770 °F

técnicas

HPLC: suitable
gas chromatography (GC): suitable

índice de refracción

n20/D 1.476 (lit.)

bp

86.7 °C (lit.)

mp

−84.8 °C (lit.)

densidad

1.463 g/mL at 25 °C (lit.)

aplicaciones

pharmaceutical (small molecule)

formato

single component solution

temp. de almacenamiento

2-30°C

cadena SMILES

Cl\C=C(\Cl)Cl

InChI

1S/C2HCl3/c3-1-2(4)5/h1H

Clave InChI

XSTXAVWGXDQKEL-UHFFFAOYSA-N

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Descripción general

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Residual Solvent - Trichloroethylene belongs to the group of class 2 residual solvents. The use of class 2 solvents should be limited in drug substances, excipients, dietary ingredients, and official products because of the inherent toxicities of these residual solvents. Trichloroethylene is a volatile and chlorinated organic compound, which finds applications as a solvent and greasing agent.

Aplicación

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Otras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota al pie de página

To see an example of a Certificate of Analysis for this material enter LRAA0678 in the slot below. This is an example certificate only and may not be the lot that you receive.

Pictogramas

Health hazard

Palabra de señalización

Danger

Frases de peligro

Clasificaciones de peligro

Carc. 1B

Código de clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

188.6 °F - closed cup

Punto de inflamabilidad (°C)

87 °C - closed cup


Listados normativos

Los listados normativos se proporcionan para los productos químicos principalmente. Para los productos no químicos sólo se puede proporcionar información limitada. Si no hay ninguna entrada, significa que ninguno de los componentes está en la lista. Es obligación del usuario garantizar el uso seguro y legal del producto.

EU REACH SVHC Candidate List

CAS No.

EU REACH Annex XVII (Restriction List)

CAS No.

EU REACH Annex XIV (Authorisation List)

CAS No.

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Certificados de análisis (COA)

Lot/Batch Number

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Los clientes también vieron

Yih-Horng Shiao
Environmental and molecular mutagenesis, 50(1), 68-77 (2008-11-26)
Trichloroethylene (TCE), an organic solvent commonly used for metal degreasing and as a chemical additive, is a significant environmental contaminant that poses health concerns in humans. The US Environmental Protection Agency (EPA) is currently revising the 2001 TCE human risk
Jane C Caldwell et al.
Environmental and molecular mutagenesis, 49(2), 142-154 (2007-11-02)
The mode(s) of action (MOA) of a pollutant for adverse health effects may be dependent on the mixture of metabolites resulting from exposure to a single agent and may also be affected by coexposure to pollutants that have similar targets
Cheryl Siegel Scott et al.
International journal of environmental research and public health, 8(11), 4238-4272 (2011-12-14)
We conducted a meta-analysis focusing on studies with high potential for trichloroethylene (TCE) exposure to provide quantitative evaluations of the evidence for associations between TCE exposure and kidney, liver, and non-Hodgkin lymphoma (NHL) cancers. A systematic review documenting essential design
Jane C Caldwell et al.
Environmental health perspectives, 114(9), 1457-1463 (2006-09-13)
Trichloroethylene (TCE) exposure has been associated with increased risk of liver and kidney cancer in both laboratory animal and epidemiologic studies. The U.S. Environmental Protection Agency 2001 draft TCE risk assessment concluded that it is difficult to determine which TCE
Berit Bakke et al.
Journal of occupational and environmental hygiene, 4(5), 375-390 (2007-04-25)
This article describes a systematic review of the industrial hygiene literature for uses of trichloroethylene (TCE) in industry for the exposure assessment of two population-based case control studies of brain cancer in the United States. Papers and reports that address

Protocolos

GC Analysis of Class 2 Residual Solvents on OVI-G43

US EPA Method TO-17: GC Analysis of Volatiles on VOCOL® after Collection/Desorption using Air Toxics Tube

US EPA Method 8260: GC Analysis of Volatiles on SPB®-624 after Purge & Trap using "K" Trap, Fast GC Analysis

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