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Documentos clave

E1310000

Erythromycin B

European Pharmacopoeia (EP) Reference Standard

Sinónimos:

12-Deoxyerythromycin

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About This Item

Fórmula empírica (notación de Hill):
C37H67NO12
Número de CAS:
Peso molecular:
717.93
Número MDL:
Código UNSPSC:
41116107
NACRES:
NA.24

grado

pharmaceutical primary standard

familia API

erythromycin

fabricante / nombre comercial

EDQM

aplicaciones

pharmaceutical (small molecule)

Formato

neat

cadena SMILES

N(C1C(C(OC(C1)C)O[C@H]2[C@@](C[C@H](C(=O)[C@@H]([C@H]([C@H]([C@H](OC(=O)[C@@H]([C@H](C2C)OC3OC(C(C(C3)(OC)C)O)C)C)CC)C)O)C)C)(O)C)O)(C)C

InChI

1S/C37H67NO12/c1-14-26-20(4)29(40)21(5)28(39)18(2)16-36(9,44)33(50-35-30(41)25(38(11)12)15-19(3)46-35)22(6)31(23(7)34(43)48-26)49-27-17-37(10,45-13)32(42)24(8)47-27/h18-27,29-33,35,40-42,44H,14-17H2,1-13H3/t18-,19?,20+,21+,22?,23-,24?,25?,26-,27?,29+,30?,31+,32?,33-,35?,36-,37?/m1/s1

Clave InChI

IDRYSCOQVVUBIJ-ZTOAHLHUSA-N

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Descripción general

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicación

Erythromycin B EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Envase

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Otras notas

Sales restrictions may apply.

Producto relacionado

Referencia del producto
Descripción
Precios

Pictogramas

Exclamation mark

Palabra de señalización

Warning

Frases de peligro

Consejos de prudencia

Clasificaciones de peligro

Eye Irrit. 2

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3


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S Morimoto et al.
The Journal of antibiotics, 43(5), 544-549 (1990-05-01)
6-O-Methylerythromycin B has been synthesized from erythromycin B via regioselective methylation of the 6-hydroxyl group in 71% overall yield. This compound shows in vitro antibacterial activity comparable to erythromycins A and B and exhibits superior in vivo activity with improved
M S Brown et al.
The Journal of antibiotics, 52(8), 742-747 (1999-12-02)
Cyclopropane carboxylic acid was fed to Saccharopolyspora erythraea NRRL 18643 (6-deoxyerythromycin producer), resulting in the production of 6-deoxy-13-cyclopropyl-erythromycin B. These studies provide further evidence that deoxyerythronolide B synthase has a relaxed specificity for the starter unit.
Q Zhang et al.
Letters in applied microbiology, 52(2), 129-137 (2010-12-24)
To overproduce erythromycin C, B or D and evaluate the effect of disruption of tailoring genes eryK and eryG in an industrial erythromycin producer. The tailoring genes eryG and eryK were inactivated individually or simultaneously by targeted gene disruption in
M N Mordi et al.
Journal of medicinal chemistry, 43(3), 467-474 (2000-02-12)
One of the major drawbacks in the use of the antibiotic erythromycin A is its extreme acid sensitivity, leading to degradation in the stomach following oral administration. The modern derivative clarithromycin degrades by a different mechanism and much more slowly.
Sara Bogialli et al.
Rapid communications in mass spectrometry : RCM, 21(2), 237-246 (2006-12-16)
A rapid and simple sample preparation procedure for determining residues of antibiotics of the class of macrolides and lincomycin in whole milk and yoghurt by liquid chromatography/tandem mass spectrometry (LC/MS/MS) is presented. The method is based on the matrix solid-phase

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