85886

Streptomycin solution

~1 mg/mL in 1 mM EDTA, analytical standard

• Fórmula empírica (notación de Hill): C₂₁H₃₉N₇O₁₂ · 1.5H₂SO₄
• Número de CAS: 3810-74-0
• Peso molecular: 728.69
• Número MDL: MFCD00037023
• Código UNSPSC: 41116107
• ID de la sustancia en PubChem: 329769423
• NACRES: NA.24

Propiedades

• grado: analytical standard
• Nivel de calidad: 100
• Formulario: liquid
• concentración: ~1 mg/mL in 1 mM EDTA
• técnicas: HPLC: suitable; gas chromatography (GC): suitable
• color: colorless
• espectro de actividad antibiótica: Gram-negative bacteria; Gram-positive bacteria; mycobacteria
• aplicaciones: pharmaceutical (small molecule)
• Formato: single component solution
• Modo de acción: protein synthesis | interferes
• temp. de almacenamiento: 2-8°C
• cadena SMILES: OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@H]2[C@@H](O[C@@H](C)[C@]2(O)C=O)O[C@@H]3[C@@H](O)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]3NC(N)=N.CN[C@H]4[C@H](O)[C@@H](O)[C@H](CO)O[C@H]4O[C@H]5[C@@H](O[C@@H](C)[C@]5(O)C=O)O[C@@H]6[C@@H](O)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]6NC(N)=N
• InChI: 1S/2C21H39N7O12.3H2O4S/c2*1-5-21(36,4-30)16(40-17-9(26-2)13(34)10(31)6(3-29)38-17)18(37-5)39-15-8(28-20(24)25)11(32)7(27-19(22)23)12(33)14(15)35;3*1-5(2,3)4/h2*4-18,26,29,31-36H,3H2,1-2H3,(H4,22,23,27)(H4,24,25,28);3*(H2,1,2,3,4)/t2*5-,6-,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,21+;;;/m00.../s1
• Clave InChI: QTENRWWVYAAPBI-YZTFXSNBSA-N

Descripción

Descripción general

Chemical structure: aminoglycoside

Aplicación

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Streptomycin is used to study mechanisms of streptomycin resistance and is often used together with penicillin and other agents to inhibit bacterial contamination in cell culture applications. It is recommended for use in molecular biology applications at 25-50μg/mL, in cell culture applications at 100 mg/L and in embryo culture at 50 mg/L.

Streptomycin solution has been used as a standard in the determination of streptomycin, present in honey using high performance liquid chromatography(HPLC).

Acciones bioquímicas o fisiológicas

Mode of Action: Streptomycin acts by inhibiting prokaryote protein synthesis by binding to the S12 protein of the 30S ribosomal subunit, thus preventing the transition from imitation complex to chain-elongating ribosome. This causes miscoding or inhibits initiation.

Mode of Resistance: A mutation in rpsL, a gene for S12 ribosomal protein, prevents binding of streptomycin to the ribosome. An aminoglycoside phosphotransferase also inactivates streptomycin.

Antimicrobial Spectrum: Streptomycin acts against gram-negative and gram-positive bacteria.

Envase

10ml

Nota de preparación

This product contains 1 mg/mL Streptomycin in 1 mM EDTA and should be stored at 2-8°C.

Otras notas

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves